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10.3390/v7062771

http://scihub22266oqcxt.onion/10.3390/v7062771
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C4488738!4488738!26110585
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suck abstract from ncbi


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pmid26110585      Viruses 2015 ; 7 (6): 3261-84
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  • Viral Membrane Channels: Role and Function in the Virus Life Cycle #MMPMID26110585
  • Sze CW; Tan YJ
  • Viruses 2015[Jun]; 7 (6): 3261-84 PMID26110585show ga
  • Viroporins are small, hydrophobic trans-membrane viral proteins that oligomerize to form hydrophilic pores in the host cell membranes. These proteins are crucial for the pathogenicity and replication of viruses as they aid in various stages of the viral life cycle, from genome uncoating to viral release. In addition, the ion channel activity of viroporin causes disruption in the cellular ion homeostasis, in particular the calcium ion. Fluctuation in the calcium level triggers the activation of the host defensive programmed cell death pathways as well as the inflammasome, which in turn are being subverted for the viruses? replication benefits. This review article summarizes recent developments in the functional investigation of viroporins from various viruses and their contributions to viral replication and virulence.
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