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10.3390/v7062756 http://scihub22266oqcxt.onion/10.3390/v7062756 C4488723!4488723 !26110582     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26110582 &cmd=llinks): Failed to open stream: HTTP request failed! 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Recombinant Immunomodulating Lentogenic or Mesogenic Oncolytic Newcastle Disease Virus for Treatment of Pancreatic Adenocarcinoma |pdf=|usr=}}{{26110582 }} gab.com Text Recombinant Immunomodulating Lentogenic or Mesogenic Oncolytic Newcastle Disease Virus for Treatment of Pancreatic Adenocarcinoma JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=26110582 #FOAvip Oncolytic Newcastle disease virus (NDV) might be a promising new therapeutic agent for the treatment of pancreatic cancer. We evaluated recombinant NDVs (rNDVs) expressing interferon (rNDV-hIFN?-F?) or an IFN antagonistic protein (rNDV-NS1-F?), as well as rNDV with increased virulence (rNDV-F?aa) for oncolytic efficacy in human pancreatic adenocarcinoma cells. Expression of additional proteins did not hamper virus replication or cytotoxic effects on itself. However, expression of interferon, but not NS1, resulted in loss of multicycle replication. Conversely, increasing the virulence (rNDV-F?aa) resulted in enhanced replication of the virus. Type I interferon was produced in high amounts by all tumor cells inoculated with rNDV-hIFN? -F?, while inoculation with rNDV-NS1-F? resulted in a complete block of interferon production in most cells. Inoculation of human pancreatic adenocarcinoma cells with rNDV-F?aa caused markedly more cytotoxicity compared to rNDV-F?, while inoculation with rNDV?-hIFN -F? and rNDV-NS1-F? induced cytotoxic effects comparable to those induced by the parental rNDV-F?. Evaluation in vivo using mice bearing subcutaneous pancreatic cancer xenografts revealed that only intratumoral injection with rNDV-F?aa resulted in regression of tumors. We conclude that although lentogenic rNDVs harboring proteins that modulate the type I interferon pathway proteins do have an oncolytic effect, a more virulent mesogenic rNDV might be needed to improve oncolytic efficacy. Twit Text FOAVip Recombinant Immunomodulating Lentogenic or Mesogenic Oncolytic Newcastle Disease Virus for Treatment of Pancreatic Adenocarcinoma ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=26110582 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26110582 #FOAvip English Wikipedia <ref>{{Cite pmid|26110582 }}</ref> Recombinant Immunomodulating Lentogenic or Mesogenic Oncolytic Newcastle Disease Virus for Treatment of Pancreatic Adenocarcinoma #MMPMID26110582 Buijs P ; van Nieuwkoop S ; Vaes V ; Fouchier R ; van Eijck C ; van den Hoogen B Viruses 2015[Jun]; 7 (6 ): 2980-98 PMID26110582 show ga Oncolytic Newcastle disease virus (NDV) might be a promising new therapeutic agent for the treatment of pancreatic cancer. We evaluated recombinant NDVs (rNDVs) expressing interferon (rNDV-hIFN?-F?) or an IFN antagonistic protein (rNDV-NS1-F?), as well as rNDV with increased virulence (rNDV-F?aa) for oncolytic efficacy in human pancreatic adenocarcinoma cells. Expression of additional proteins did not hamper virus replication or cytotoxic effects on itself. However, expression of interferon, but not NS1, resulted in loss of multicycle replication. Conversely, increasing the virulence (rNDV-F?aa) resulted in enhanced replication of the virus. Type I interferon was produced in high amounts by all tumor cells inoculated with rNDV-hIFN? -F?, while inoculation with rNDV-NS1-F? resulted in a complete block of interferon production in most cells. Inoculation of human pancreatic adenocarcinoma cells with rNDV-F?aa caused markedly more cytotoxicity compared to rNDV-F?, while inoculation with rNDV?-hIFN -F? and rNDV-NS1-F? induced cytotoxic effects comparable to those induced by the parental rNDV-F?. Evaluation in vivo using mice bearing subcutaneous pancreatic cancer xenografts revealed that only intratumoral injection with rNDV-F?aa resulted in regression of tumors. We conclude that although lentogenic rNDVs harboring proteins that modulate the type I interferon pathway proteins do have an oncolytic effect, a more virulent mesogenic rNDV might be needed to improve oncolytic efficacy. |Adenocarcinoma/pathology/*therapy [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Heterografts [MESH] |Humans [MESH] |Mice, Nude [MESH] |Newcastle disease virus/genetics/*growth & development [MESH] |Oncolytic Virotherapy/*methods [MESH] |Oncolytic Viruses/genetics/*growth & development [MESH] |Pancreatic Neoplasms/pathology/*therapy [MESH]Recombinant Immunomodulating Lentogenic or Mesogenic Oncolytic Newcast(epmc).pdf DeepDyve Pubget Overpricing