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2015 ; 10
(6
): e0130772
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English Wikipedia
Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a
Regulatory T Cell Response
#MMPMID26126176
Sampson JF
; Hasegawa E
; Mulki L
; Suryawanshi A
; Jiang S
; Chen WS
; Rabinovich GA
; Connor KM
; Panjwani N
PLoS One
2015[]; 10
(6
): e0130772
PMID26126176
show ga
Galectins have emerged as potent immunoregulatory agents that control chronic
inflammation through distinct mechanisms. Here, we report that treatment with
Galectin-8 (Gal-8), a tandem-repeat member of the galectin family, reduces
retinal pathology and prevents photoreceptor cell damage in a murine model of
experimental autoimmune uveitis. Gal-8 treatment increased the number of
regulatory T cells (Treg) in both the draining lymph node (dLN) and the inflamed
retina. Moreover, a greater percentage of Treg cells in the dLN and retina of
Gal-8 treated animals expressed the inhibitory coreceptor cytotoxic T lymphocyte
antigen (CTLA)-4, the immunosuppressive cytokine IL-10, and the tissue-homing
integrin CD103. Treg cells in the retina of Gal-8-treated mice were primarily
inducible Treg cells that lack the expression of neuropilin-1. In addition, Gal-8
treatment blunted production of inflammatory cytokines by retinal T helper type
(TH) 1 and TH17 cells. The effect of Gal-8 on T cell differentiation and/or
function was specific for tissues undergoing an active immune response, as Gal-8
treatment had no effect on T cell populations in the spleen. Given the need for
rational therapies for managing human uveitis, Gal-8 emerges as an attractive
therapeutic candidate not only for treating retinal autoimmune diseases, but also
for other TH1- and TH17-mediated inflammatory disorders.
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