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10.1186/s13578-015-0027-9 http://scihub22266oqcxt.onion/10.1186/s13578-015-0027-9 C4487574!4487574!26137216     free     free     free       Cell+Biosci 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26137216|t=2015. Application of CRISPR/Cas9 for biomedical discoveries |pdf=|usr=}}{{26137216}} gab.com Text Application of CRISPR/Cas9 for biomedical discoveries JO: Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=26137216 #FOAvip The Clustered Regions of Interspersed Palindromic Repeats-Cas9 (CRISPR/Cas9), a viral defense system found in bacteria and archaea, has emerged as a tour de force genome editing tool. The CRISPR/Cas9 system is much easier to customize and optimize because the site selection for DNA cleavage is guided by a short sequence of RNA rather than an engineered protein as in the systems of zinc finger nucleases (ZFN), transcription activator?like effector nucleases (TALEN), and meganucleases. Although it still suffers from some off-target effects, the CRISPR/Cas9 system has been broadly and successfully applied for biomedical discoveries in a number of areas. In this review, we present a brief history and development of the CRISPR system and focus on the application of this genome editing technology for biomedical discoveries. We then present concise concluding remarks and future directions for this fast moving field. Twit Text FOAVip Application of CRISPR/Cas9 for biomedical discoveries ????Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=26137216 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26137216 #FOAvip English Wikipedia <ref>{{Cite pmid|26137216}}</ref> Application of CRISPR/Cas9 for biomedical discoveries #MMPMID26137216 Riordan SM; Heruth DP; Zhang LQ; Ye SQ Cell Biosci 2015[]; 5 (ä): ä PMID26137216show ga The Clustered Regions of Interspersed Palindromic Repeats-Cas9 (CRISPR/Cas9), a viral defense system found in bacteria and archaea, has emerged as a tour de force genome editing tool. The CRISPR/Cas9 system is much easier to customize and optimize because the site selection for DNA cleavage is guided by a short sequence of RNA rather than an engineered protein as in the systems of zinc finger nucleases (ZFN), transcription activator?like effector nucleases (TALEN), and meganucleases. Although it still suffers from some off-target effects, the CRISPR/Cas9 system has been broadly and successfully applied for biomedical discoveries in a number of areas. In this review, we present a brief history and development of the CRISPR system and focus on the application of this genome editing technology for biomedical discoveries. We then present concise concluding remarks and future directions for this fast moving field. äApplication of CRISPR/Cas9 for biomedical discoveries (epmc).pdf DeepDyve Pubget Overpricing