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10.1038/srep12010

http://scihub22266oqcxt.onion/10.1038/srep12010
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C4487233!4487233!26131602
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suck abstract from ncbi


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pmid26131602      Sci+Rep 2015 ; 5 (ä): ä
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  • A systematic analysis of human lipocalin family and its expression in esophageal carcinoma #MMPMID26131602
  • Du ZP; Wu BL; Wu X; Lin XH; Qiu XY; Zhan XF; Wang SH; Shen JH; Zheng CP; Wu ZY; Xu LY; Wang D; Li EM
  • Sci Rep 2015[]; 5 (ä): ä PMID26131602show ga
  • The lipocalin proteins (lipocalins) are a large family of small proteins characterized by low sequence similarity and highly conserved crystal structures. Lipocalins have been found to play important roles in many human diseases. For this reason, a systemic analysis of the molecular properties of human lipocalins is essential. In this study, human lipocalins were found to contain four structurally conserved regions (SCRs) and could be divided into two subgroups. A human lipocalin protein-protein interaction network (PPIN) was constructed and integrated with their expression data in esophageal carcinoma. Many lipocalins showed obvious co-expression patterns in esophageal carcinoma. Their subcellular distributions also suggested these lipocalins may transfer signals from the extracellular space to the nucleus using the pathway-like paths. These analyses also expanded our knowledge about this human ancient protein family in the background of esophageal carcinoma.
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