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10.3892/ol.2015.3165

http://scihub22266oqcxt.onion/10.3892/ol.2015.3165
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C4487103!4487103!26171017
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suck abstract from ncbi


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pmid26171017      Oncol+Lett 2015 ; 10 (1): 291-6
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  • Upregulation of H19 promotes invasion and induces epithelial-to-mesenchymal transition in esophageal cancer #MMPMID26171017
  • HUANG C; CAO L; QIU L; DAI X; MA L; ZHOU Y; LI H; GAO M; LI W; ZHANG Q; HAN K; LV H
  • Oncol Lett 2015[Jul]; 10 (1): 291-6 PMID26171017show ga
  • Long non-coding RNAs (lncRNAs) have previously been reported to be involved in cancer invasion, proliferation and apoptosis. However, the association between the lncRNA, H19, and esophageal cancer (EC) has remained elusive. In the present study, reverse transcription quantitative-polymerase chain reaction revealed that the expression of H19 was significantly increased and associated with tumor depth and metastasis in 133 EC samples. Furthermore, MTT and Transwell assays revealed that overexpression of H19 in vitro promoted the proliferation and invasion of EC cell lines, whereas knockdown of H19 inhibited the proliferation and invasion of EC cell lines. In addition, it was identified that an upregulation of H19 induced epithelial-to-mesenchymal transition, while the opposite effect was observed following the downregulation of H19. In conclusion, H19 has a significant role in the development of EC and may serve as a potential prognostic marker and therapeutic target for EC.
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