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10.3978/j.issn.2305-5839.2015.04.25 http://scihub22266oqcxt.onion/10.3978/j.issn.2305-5839.2015.04.25 C4486914!4486914!26207223     free     free     free       Ann+Transl+Med 2015 ; 3 (10): ä Nephropedia Template TP {{tp|p=26207223|t=2015. The multiple facets of alpha-1-antitrypsin |pdf=|usr=}}{{26207223}} gab.com Text The multiple facets of alpha-1-antitrypsin JO: Ann Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=26207223 #FOAvip Alpha-1-antitrypsin (AAT) is recognised as a potent inhibitor of serine proteinases. Genetic deficiency is associated with several neutrophilic diseases including severe emphysema. This is believed to reflect the loss of inhibition of neutrophilic serine proteinases that then result in local tissue damage (the proteinase/antiprotease hypothesis). In recent years the role of AAT in the control of inflammatory and immunological processes has become identified. Although in some instances this may reflect its ability to control pro-inflammatory effects of serine proteinases it has also become recognised that it has non proteolytic mediated functions. This poly functional role is starting to become recognised offering a possibility of its use as a therapeutic agent in many clinical disease areas. The current review explores both the traditional and non-traditional function of AAT through published literature. Twit Text FOAVip The multiple facets of alpha-1-antitrypsin ????Ann Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=26207223 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26207223 #FOAvip English Wikipedia <ref>{{Cite pmid|26207223}}</ref> The multiple facets of alpha-1-antitrypsin #MMPMID26207223 Stockley RA Ann Transl Med 2015[Jun]; 3 (10): ä PMID26207223show ga Alpha-1-antitrypsin (AAT) is recognised as a potent inhibitor of serine proteinases. Genetic deficiency is associated with several neutrophilic diseases including severe emphysema. This is believed to reflect the loss of inhibition of neutrophilic serine proteinases that then result in local tissue damage (the proteinase/antiprotease hypothesis). In recent years the role of AAT in the control of inflammatory and immunological processes has become identified. Although in some instances this may reflect its ability to control pro-inflammatory effects of serine proteinases it has also become recognised that it has non proteolytic mediated functions. This poly functional role is starting to become recognised offering a possibility of its use as a therapeutic agent in many clinical disease areas. The current review explores both the traditional and non-traditional function of AAT through published literature. äThe multiple facets of alpha-1-antitrypsin (epmc).pdf DeepDyve Pubget Overpricing