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10.1126/science.1242454 http://scihub22266oqcxt.onion/10.1126/science.1242454 C4486656!4486656!24115444     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2013 ; 342 (6155): 1242454 Nephropedia Template TP {{tp|p=24115444|t=2013. Fueling Immunity: Insights into Metabolism and Lymphocyte Function |pdf=|usr=}}{{24115444}} gab.com Text Fueling Immunity: Insights into Metabolism and Lymphocyte Function JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=24115444 #FOAvip Lymphocytes face major metabolic challenges upon activation. They must meet the bioenergetic and biosynthetic demands of increased cell proliferation and also adapt to changing environmental conditions, in which nutrients and oxygen may be limiting. An emerging theme in immunology is that metabolic reprogramming and lymphocyte activation are intricately linked. However, why T cells adopt specific metabolic programs and the impact that these programs have on T cell function and, ultimately, immunological outcome remain unclear. Research on tumor cell metabolism has provided valuable insight into metabolic pathways important for cell proliferation and the influence of metabolites themselves on signal transduction and epigenetic programming. In this Review, we highlight emerging concepts regarding metabolic reprogramming in proliferating cells and discuss their potential impact on T cell fate and function. Twit Text FOAVip Fueling Immunity: Insights into Metabolism and Lymphocyte Function ????Science http://www.kidney.de/pget.php?&tw=1&pmid=24115444 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24115444 #FOAvip English Wikipedia <ref>{{Cite pmid|24115444}}</ref> Fueling Immunity: Insights into Metabolism and Lymphocyte Function #MMPMID24115444 Pearce EL; Poffenberger MC; Chang CH; Jones RG Science 2013[Oct]; 342 (6155): 1242454 PMID24115444show ga Lymphocytes face major metabolic challenges upon activation. They must meet the bioenergetic and biosynthetic demands of increased cell proliferation and also adapt to changing environmental conditions, in which nutrients and oxygen may be limiting. An emerging theme in immunology is that metabolic reprogramming and lymphocyte activation are intricately linked. However, why T cells adopt specific metabolic programs and the impact that these programs have on T cell function and, ultimately, immunological outcome remain unclear. Research on tumor cell metabolism has provided valuable insight into metabolic pathways important for cell proliferation and the influence of metabolites themselves on signal transduction and epigenetic programming. In this Review, we highlight emerging concepts regarding metabolic reprogramming in proliferating cells and discuss their potential impact on T cell fate and function. äFueling Immunity: Insights into Metabolism and Lymphocyte Function (epmc).pdf DeepDyve Pubget Overpricing