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10.1186/s12915-015-0158-9

http://scihub22266oqcxt.onion/10.1186/s12915-015-0158-9
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C4486427!4486427!26129844
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suck abstract from ncbi


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pmid26129844      BMC+Biol 2015 ; 13 (ä): ä
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  • Models in biology: lessons from modeling regulation of the eukaryotic cell cycle #MMPMID26129844
  • Tyson JJ; Novák B
  • BMC Biol 2015[]; 13 (ä): ä PMID26129844show ga
  • In this essay we illustrate some general principles of mathematical modeling in biology by our experiences in studying the molecular regulatory network underlying eukaryotic cell division. We discuss how and why the models moved from simple, parsimonious cartoons to more complex, detailed mechanisms with many kinetic parameters. We describe how the mature models made surprising and informative predictions about the control system that were later confirmed experimentally. Along the way, we comment on the ?parameter estimation problem? and conclude with an appeal for a greater role for mathematical models in molecular cell biology.
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