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10.1126/science.1226804 http://scihub22266oqcxt.onion/10.1126/science.1226804 C4486416!4486416!23239739     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2012 ; 338 (6113): 1476-80 Nephropedia Template TP {{tp|p=23239739|t=2012. Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism |pdf=|usr=}}{{23239739}} gab.com Text Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=23239739 #FOAvip The formation of repetitive structures (such as stripes) in nature is often consistent with a reaction-diffusion mechanism, or Turing model, of self-organizing systems. We used mouse genetics to analyze how digit patterning (an iterative digit/nondigit pattern) is generated. We showed that the progressive reduction in Hoxa13 and Hoxd11-Hoxd13 genes (hereafter referred to as distal Hox genes) from the Gli3-null background results in progressively more severe polydactyly, displaying thinner and densely packed digits. Combined with computer modeling, our results argue for a Turing-type mechanism underlying digit patterning, in which the dose of distal Hox genes modulates the digit period or wavelength. The phenotypic similarity with fish-fin endoskeleton patterns suggests that the pentadactyl state has been achieved through modification of an ancestral Turing-type mechanism. Twit Text FOAVip Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism ????Science http://www.kidney.de/pget.php?&tw=1&pmid=23239739 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23239739 #FOAvip English Wikipedia <ref>{{Cite pmid|23239739}}</ref> Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism #MMPMID23239739 Sheth R; Marcon L; Félix Bastida M; Junco M; Quintana L; Dahn R; Kmita M; Sharpe J; Ros MA Science 2012[Dec]; 338 (6113): 1476-80 PMID23239739show ga The formation of repetitive structures (such as stripes) in nature is often consistent with a reaction-diffusion mechanism, or Turing model, of self-organizing systems. We used mouse genetics to analyze how digit patterning (an iterative digit/nondigit pattern) is generated. We showed that the progressive reduction in Hoxa13 and Hoxd11-Hoxd13 genes (hereafter referred to as distal Hox genes) from the Gli3-null background results in progressively more severe polydactyly, displaying thinner and densely packed digits. Combined with computer modeling, our results argue for a Turing-type mechanism underlying digit patterning, in which the dose of distal Hox genes modulates the digit period or wavelength. The phenotypic similarity with fish-fin endoskeleton patterns suggests that the pentadactyl state has been achieved through modification of an ancestral Turing-type mechanism. äHox Genes Regulate Digit Patterning by Controlling the Wavelength of a(epmc).pdf DeepDyve Pubget Overpricing