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10.1089/ars.2014.6219

http://scihub22266oqcxt.onion/10.1089/ars.2014.6219
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C4486147!4486147!25566681
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suck abstract from ncbi


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pmid25566681      Antioxid+Redox+Signal 2015 ; 22 (18): 1667-80
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  • Cardiolipin Signaling Mechanisms: Collapse of Asymmetry and Oxidation #MMPMID25566681
  • Kagan VE; Tyurina YY; Tyurin VA; Mohammadyani D; Angeli JPF; Baranov SV; Klein-Seetharaman J; Friedlander RM; Mallampalli RK; Conrad M; Bayir H
  • Antioxid Redox Signal 2015[Jun]; 22 (18): 1667-80 PMID25566681show ga
  • Significance: An ancient anionic phospholipid, cardiolipin (CL), ubiquitously present in prokaryotic and eukaryotic membranes, is essential for several structural and functional purposes. Recent Advances: The emerging role of CLs in signaling has become the focus of many studies. Critical Issues: In this work, we describe two major pathways through which mitochondrial CLs may fulfill the signaling functions via utilization of their (i) asymmetric distribution across membranes and translocations, leading to the surface externalization and (ii) ability to undergo oxidation reactions to yield the signature products recognizable by the executionary machinery of cells. Future Directions: We present a concept that CLs and their oxidation/hydrolysis products constitute a rich communication language utilized by mitochondria of eukaryotic cells for diversified regulation of cell physiology and metabolism as well as for inter-cellular interactions. Antioxid. Redox Signal. 22, 1667?1680.
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