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Serum Cystatin C for the Diagnosis of Acute Kidney Injury in Patients Admitted in
the Emergency Department
#MMPMID26170529
Bongiovanni C
; Magrini L
; Salerno G
; Gori CS
; Cardelli P
; Hur M
; Buggi M
; Di Somma S
Dis Markers
2015[]; 2015
(?): 416059
PMID26170529
show ga
BACKGROUND: Early diagnosis of acute kidney injury (AKI) at emergency department
(ED) is a challenging issue. Current diagnostic criteria for AKI poorly recognize
early renal dysfunction and may cause delayed diagnosis. We evaluated the use of
serum cystatin C (CysC) for the early and accurate diagnosis of AKI in patients
hospitalized from the ED. METHODS: In a total of 198 patients (105 males and 93
females), serum CysC, serum creatinine (sCr), and estimated glomerular filtration
rate (eGFR) were calculated at 0, 6, 12, 24, 48, and 72 hours after presentation
to the ED. We compared two groups according to the presence or absence of AKI.
RESULTS: Serial assessment of CysC, sCr, and eGFR was not a strong, reliable tool
to distinguish AKI from non-AKI. CysC > 1.44 mg/L at admission, both alone (Odds
Ratio = 5.04; 95%CI 2.20-11.52; P < 0.0002) and in combination with sCr and eGFR
(Odds Ratio = 5.71; 95%CI 1.86-17.55; P < 0.002), was a strong predictor for the
risk of AKI. CONCLUSIONS: Serial assessment of CysC is not superior to sCr and
eGFR in distinguishing AKI from non-AKI. Admission CysC, both alone and in
combination with sCr and eGFR, could be considered a powerful tool for the
prediction of AKI in ED patients.
|Acute Kidney Injury/*blood/diagnosis
[MESH]
|Aged
[MESH]
|Aged, 80 and over
[MESH]
|Biomarkers/blood
[MESH]
|Cystatin C/*blood
[MESH]
|Emergency Service, Hospital/statistics & numerical data
[MESH]
free
free
free
