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2015 ; 4
(6
): e1009288
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Implications of understanding the signaling, cellular, and cytotoxic mechanisms
afforded by afucosylated antibodies
#MMPMID26155429
Liu SD
; Lowe JB
Oncoimmunology
2015[Jun]; 4
(6
): e1009288
PMID26155429
show ga
Afucosylated antibodies potentiate natural killer (NK) cell-mediated
antibody-dependent cellular cytotoxicity (ADCC) by enhancing signaling pathways
and cellular processes, which in turn, increases cytotoxic potential.
Importantly, a better understanding of these processes and properties will aid in
exploiting them to help design therapeutic antibodies and strategies that may be
of the greatest benefit to patients.