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10.1159/000381990 http://scihub22266oqcxt.onion/10.1159/000381990 C4485546!4485546!25967288     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25967288&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nephron 2015 ; 130 (ä): 92-8 Nephropedia Template TP {{tp|p=25967288|t=2015. The gut as a source of inflammation in chronic kidney disease |pdf=|usr=}}{{25967288}} gab.com Text The gut as a source of inflammation in chronic kidney disease JO: Nephron http://www.kidney.de/pget.php?&tw=1&pmid=25967288 #FOAvip Chronic inflammation is a non-traditional risk factor for cardiovascular mortality in the chronic kidney disease (CKD) population. In recent years the gastrointestinal tract has emerged as a major instigator of systemic inflammation in CKD. Post-mortem studies previously discovered gut wall inflammation present throughout the digestive tract in chronic dialysis patients. In CKD animals, colon wall inflammation is associated with breakdown of the epithelial tight junction barrier (?leaky gut?) and translocation of bacterial DNA and endotoxin into the bloodstream. Gut bacterial DNA and endotoxin have also been detected in the serum from CKD and dialysis patients, whereby endotoxin levels increase with CKD stage and correlate with severity of systemic inflammation in the dialysis population. The CKD diet that is low in plant fiber and symbiotic organisms (in adherence with low potassium, low phosphorus intake) can alter the normal gut microbiome, leading to overgrowth of bacteria that produce uremic toxins such as cresyl and indoxyl molecules. The translocation of these toxins from the ?leaky gut? into the bloodstream further promotes systemic inflammation, adverse cardiovascular outcomes and CKD progression. Data is lacking on optimal fiber and yogurt consumption in CKD that would favor growth of a more symbiotic microbiome while avoiding potassium and phosphorus overload. Prebiotic and probiotic formulations have shown promise in small clinical trials, in terms of lowering serum levels of uremic toxins and improving quality of life. The evidence points to a strong relationship between intestinal inflammation and adverse outcomes in CKD, and more trials investigating gut-targeted therapeutics are needed. Twit Text FOAVip The gut as a source of inflammation in chronic kidney disease ????Nephron http://www.kidney.de/pget.php?&tw=1&pmid=25967288 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25967288 #FOAvip English Wikipedia <ref>{{Cite pmid|25967288}}</ref> The gut as a source of inflammation in chronic kidney disease #MMPMID25967288 Lau WL; Kalantar-Zadeh K; Vaziri ND Nephron 2015[]; 130 (ä): 92-8 PMID25967288show ga Chronic inflammation is a non-traditional risk factor for cardiovascular mortality in the chronic kidney disease (CKD) population. In recent years the gastrointestinal tract has emerged as a major instigator of systemic inflammation in CKD. Post-mortem studies previously discovered gut wall inflammation present throughout the digestive tract in chronic dialysis patients. In CKD animals, colon wall inflammation is associated with breakdown of the epithelial tight junction barrier (?leaky gut?) and translocation of bacterial DNA and endotoxin into the bloodstream. Gut bacterial DNA and endotoxin have also been detected in the serum from CKD and dialysis patients, whereby endotoxin levels increase with CKD stage and correlate with severity of systemic inflammation in the dialysis population. The CKD diet that is low in plant fiber and symbiotic organisms (in adherence with low potassium, low phosphorus intake) can alter the normal gut microbiome, leading to overgrowth of bacteria that produce uremic toxins such as cresyl and indoxyl molecules. The translocation of these toxins from the ?leaky gut? into the bloodstream further promotes systemic inflammation, adverse cardiovascular outcomes and CKD progression. Data is lacking on optimal fiber and yogurt consumption in CKD that would favor growth of a more symbiotic microbiome while avoiding potassium and phosphorus overload. Prebiotic and probiotic formulations have shown promise in small clinical trials, in terms of lowering serum levels of uremic toxins and improving quality of life. The evidence points to a strong relationship between intestinal inflammation and adverse outcomes in CKD, and more trials investigating gut-targeted therapeutics are needed. äThe gut as a source of inflammation in chronic kidney disease (epmc).pdf DeepDyve Pubget Overpricing