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10.1038/nrcardio.2014.162 http://scihub22266oqcxt.onion/10.1038/nrcardio.2014.162 C4485434!4485434!25311230     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Cardiol 2014 ; 11 (12): 715-27 Nephropedia Template TP {{tp|p=25311230|t=2014. Cardiac valve cells and their microenvironment?insights from in vitro studies |pdf=|usr=}}{{25311230}} gab.com Text Cardiac valve cells and their microenvironment insights from in vitro studies JO: Nat Rev Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=25311230 #FOAvip During every heartbeat, cardiac valves open and close coordinately to control unidirectional flow of blood. In this dynamically challenging environment, resident valve cells actively maintain homeostasis, but the signalling between cells and their microenvironment is complex. When this homeostasis is disrupted and valve opening obstructed, haemodynamic profiles can be altered and lead to impaired cardiac function. Currently, late stages of cardiac valve diseases are treated surgically, as there are no known drug therapies to reverse or halt disease progression. Consequently investigators have sought to understand the molecular and cellular mechanisms of valvular diseases usi in vitro cell culture systems and biomaterials scaffolds that can mimic extracellular microenvironment. In this Review we describe how signals in the extra cellular matrix regulate valve cell function. We propose that the cellular context is a critical factor when studying the molecular basis of valvular diseases in vitro, and one should consider how the surrounding matrix might influence cell signalling and functional outcomes in the valve. Investigators need to build a systems level understanding of the complex signalling network involved in valve regulation, to facilitate drug target identification and promote in situ or ex vivo heart valve regeneration. Twit Text FOAVip Cardiac valve cells and their microenvironment insights from in vitro studies ????Nat Rev Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=25311230 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25311230 #FOAvip English Wikipedia <ref>{{Cite pmid|25311230}}</ref> Cardiac valve cells and their microenvironment?insights from in vitro studies #MMPMID25311230 Wang H; Leinwand LA; Anseth KS Nat Rev Cardiol 2014[Dec]; 11 (12): 715-27 PMID25311230show ga During every heartbeat, cardiac valves open and close coordinately to control unidirectional flow of blood. In this dynamically challenging environment, resident valve cells actively maintain homeostasis, but the signalling between cells and their microenvironment is complex. When this homeostasis is disrupted and valve opening obstructed, haemodynamic profiles can be altered and lead to impaired cardiac function. Currently, late stages of cardiac valve diseases are treated surgically, as there are no known drug therapies to reverse or halt disease progression. Consequently investigators have sought to understand the molecular and cellular mechanisms of valvular diseases usi in vitro cell culture systems and biomaterials scaffolds that can mimic extracellular microenvironment. In this Review we describe how signals in the extra cellular matrix regulate valve cell function. We propose that the cellular context is a critical factor when studying the molecular basis of valvular diseases in vitro, and one should consider how the surrounding matrix might influence cell signalling and functional outcomes in the valve. Investigators need to build a systems level understanding of the complex signalling network involved in valve regulation, to facilitate drug target identification and promote in situ or ex vivo heart valve regeneration. äCardiac valve cells and their microenvironment?insights from in vitro (epmc).pdf DeepDyve Pubget Overpricing