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10.1016/j.neuron.2014.12.017 http://scihub22266oqcxt.onion/10.1016/j.neuron.2014.12.017 C4485387!4485387!25521379     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuron 2014 ; 84 (6): 1240-57 Nephropedia Template TP {{tp|p=25521379|t=2014. Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number |pdf=|usr=}}{{25521379}} gab.com Text Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=25521379 #FOAvip Katanin is a microtubule-severing complex whose catalytic activities are well characterized, but whose in vivo functions are incompletely understood. Human mutations in KATNB1, which encodes the noncatalytic regulatory p80 subunit of katanin, cause severe microlissencephaly. Loss of Katnb1 in mice confirms essential roles in neurogenesis and cell survival, while loss of zebrafish katnb1 reveals specific roles for katnin p80 in early and late developmental stages. Surprisingly, Katnb1 null mutant mouse embryos display hallmarks of aberrant Sonic hedgehog signaling, including holoprosencephaly. KATNB1-deficient human cells show defective proliferation and spindle structure, while Katnb1 null fibroblasts also demonstrate a remarkable excess of centrioles, with supernumerary cilia but deficient Hedgehog signaling. Our results reveal unexpected functions for KATNB1 in regulating overall centriole, mother centriole, and cilia number, and as an essential gene for normal Hedgehog signaling during neocortical development. Twit Text FOAVip Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=25521379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25521379 #FOAvip English Wikipedia <ref>{{Cite pmid|25521379}}</ref> Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number #MMPMID25521379 Hu WF; Pomp O; Ben-Omran T; Kodani A; Henke K; Mochida GH; Yu TW; Woodworth MB; Bonnard C; Raj GS; Tan TT; Hamamy H; Masri A; Shboul M; Al Saffar M; Partlow JN; Al-Dosari M; Alazami A; Alowain M; Alkuraya FS; Reiter JF; Harris MP; Reversade B; Walsh CA Neuron 2014[Dec]; 84 (6): 1240-57 PMID25521379show ga Katanin is a microtubule-severing complex whose catalytic activities are well characterized, but whose in vivo functions are incompletely understood. Human mutations in KATNB1, which encodes the noncatalytic regulatory p80 subunit of katanin, cause severe microlissencephaly. Loss of Katnb1 in mice confirms essential roles in neurogenesis and cell survival, while loss of zebrafish katnb1 reveals specific roles for katnin p80 in early and late developmental stages. Surprisingly, Katnb1 null mutant mouse embryos display hallmarks of aberrant Sonic hedgehog signaling, including holoprosencephaly. KATNB1-deficient human cells show defective proliferation and spindle structure, while Katnb1 null fibroblasts also demonstrate a remarkable excess of centrioles, with supernumerary cilia but deficient Hedgehog signaling. Our results reveal unexpected functions for KATNB1 in regulating overall centriole, mother centriole, and cilia number, and as an essential gene for normal Hedgehog signaling during neocortical development. äKatanin p80 Regulates Human Cortical Development by Limiting Centriole(epmc).pdf DeepDyve Pubget Overpricing