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10.1038/srep11766 http://scihub22266oqcxt.onion/10.1038/srep11766 C4485318!4485318 !26123483     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26123483 &cmd=llinks): Failed to open stream: HTTP request failed! 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A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome |pdf=|usr=}}{{26123483 }} gab.com Text A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26123483 #FOAvip Currently, very few prognosticators accurately predict metastasis in cancer patients. In order to complete the metastatic cascade and successfully colonize distant sites, carcinoma cells undergo dynamic epithelial-mesenchymal-transition (EMT) and its reversal, mesenchymal-epithelial-transition (MET). While EMT-centric signatures correlate with response to therapy, they are unable to predict metastatic outcome. One reason is due to the wide range of transient phenotypes required for a tumor cell to disseminate and recreate a similar histology at distant sites. Since such dynamic cellular processes are also seen during embryo development (epithelial-like epiblast cells undergo transient EMT to generate the mesoderm, which eventually redifferentiates into epithelial tissues by MET), we sought to utilize this unique and highly conserved property of cellular plasticity to predict metastasis. Here we present the identification of a novel prognostic gene expression signature derived from mouse embryonic day 6.5 that is representative of extensive cellular plasticity, and predicts metastatic competence in human breast tumor cells. This signature may thus complement conventional clinical parameters to offer accurate prediction for outcome among multiple classes of breast cancer patients. Twit Text FOAVip A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26123483 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26123483 #FOAvip English Wikipedia <ref>{{Cite pmid|26123483 }}</ref> A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome #MMPMID26123483 Soundararajan R ; Paranjape AN ; Barsan V ; Chang JT ; Mani SA Sci Rep 2015[Jun]; 5 (ä): 11766 PMID26123483 show ga Currently, very few prognosticators accurately predict metastasis in cancer patients. In order to complete the metastatic cascade and successfully colonize distant sites, carcinoma cells undergo dynamic epithelial-mesenchymal-transition (EMT) and its reversal, mesenchymal-epithelial-transition (MET). While EMT-centric signatures correlate with response to therapy, they are unable to predict metastatic outcome. One reason is due to the wide range of transient phenotypes required for a tumor cell to disseminate and recreate a similar histology at distant sites. Since such dynamic cellular processes are also seen during embryo development (epithelial-like epiblast cells undergo transient EMT to generate the mesoderm, which eventually redifferentiates into epithelial tissues by MET), we sought to utilize this unique and highly conserved property of cellular plasticity to predict metastasis. Here we present the identification of a novel prognostic gene expression signature derived from mouse embryonic day 6.5 that is representative of extensive cellular plasticity, and predicts metastatic competence in human breast tumor cells. This signature may thus complement conventional clinical parameters to offer accurate prediction for outcome among multiple classes of breast cancer patients. |*Epithelial-Mesenchymal Transition [MESH] |Animals [MESH] |Breast Neoplasms/genetics/*metabolism/mortality/pathology [MESH] |Cell Line, Tumor [MESH] |Disease-Free Survival [MESH] |Female [MESH] |Gene Expression Regulation, Developmental [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Mice [MESH] |Mouse Embryonic Stem Cells/physiology [MESH] |Neoplasm Metastasis [MESH] |Transcriptome [MESH]A novel embryonic plasticity gene signature that predicts metastatic c(epmc).pdf DeepDyve Pubget Overpricing