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2015 ; 112
(25
): 7791-6
Nephropedia Template TP
gab.com Text
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Minimal genomes of mycoplasma-related endobacteria are plastic and contain
host-derived genes for sustained life within Glomeromycota
#MMPMID25964324
Naito M
; Morton JB
; Pawlowska TE
Proc Natl Acad Sci U S A
2015[Jun]; 112
(25
): 7791-6
PMID25964324
show ga
Arbuscular mycorrhizal fungi (AMF, Glomeromycota) colonize roots of the majority
of terrestrial plants. They provide essential minerals to their plant hosts and
receive photosynthates in return. All major lineages of AMF harbor endobacteria
classified as Mollicutes, and known as mycoplasma-related endobacteria (MRE).
Except for their substantial intrahost genetic diversity and ability to transmit
vertically, virtually nothing is known about the life history of these
endobacteria. To understand MRE biology, we sequenced metagenomes of three MRE
populations, each associated with divergent AMF hosts. We found that each AMF
species harbored a genetically distinct group of MRE. Despite vertical
transmission, all MRE populations showed extensive chromosomal rearrangements,
which we attributed to genetic recombination, activity of mobile elements, and a
history of plectroviral invasion. The MRE genomes are characterized by a highly
reduced gene content, indicating metabolic dependence on the fungal host, with
the mechanism of energy production remaining unclear. Several MRE genes encode
proteins with domains involved in protein-protein interactions with eukaryotic
hosts. In addition, the MRE genomes harbor genes horizontally acquired from AMF.
Some of these genes encode small ubiquitin-like modifier (SUMO) proteases
specific to the SUMOylation systems of eukaryotes, which MRE likely use to
manipulate their fungal host. The extent of MRE genome plasticity and reduction,
along with the large number of horizontally acquired host genes, suggests a high
degree of adaptation to the fungal host. These features, together with the
ubiquity of the MRE-Glomeromycota associations, emphasize the significance of MRE
in the biology of Glomeromycota.