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10.1073/pnas.1509193112 http://scihub22266oqcxt.onion/10.1073/pnas.1509193112 C4485122!4485122!26056301     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (25): 7743-8 Nephropedia Template TP {{tp|p=26056301|t=2015. Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells |pdf=|usr=}}{{26056301}} gab.com Text Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26056301 #FOAvip The ZBED6 (zinc finger, BED-type containing 6) transcription factor is unique to placental mammals. Its high degree of sequence conservation among placental mammals indicates that it has an essential function. Using two colorectal cancer cell lines we have, for the first time to our knowledge, completely inactivated ZBED6 by genome editing. Our results demonstrate that ZBED6 is not required for cell survival, but its ablation led to consistent changes in cell growth within cell lines but opposite trends between cell lines. The results are in line with the hypothesis that ZBED6 is a transcriptional modulator that does not determine whether or not its target genes are active but fine-tunes their expression. Thus, its effect on tumorigenesis will depend on the transcriptional state of the cell. Twit Text FOAVip Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26056301 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26056301 #FOAvip English Wikipedia <ref>{{Cite pmid|26056301}}</ref> Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells #MMPMID26056301 Akhtar Ali M; Younis S; Wallerman O; Gupta R; Andersson L; Sjöblom T Proc Natl Acad Sci U S A 2015[Jun]; 112 (25): 7743-8 PMID26056301show ga The ZBED6 (zinc finger, BED-type containing 6) transcription factor is unique to placental mammals. Its high degree of sequence conservation among placental mammals indicates that it has an essential function. Using two colorectal cancer cell lines we have, for the first time to our knowledge, completely inactivated ZBED6 by genome editing. Our results demonstrate that ZBED6 is not required for cell survival, but its ablation led to consistent changes in cell growth within cell lines but opposite trends between cell lines. The results are in line with the hypothesis that ZBED6 is a transcriptional modulator that does not determine whether or not its target genes are active but fine-tunes their expression. Thus, its effect on tumorigenesis will depend on the transcriptional state of the cell. äTranscriptional modulator ZBED6 affects cell cycle and growth of human(epmc).pdf DeepDyve Pubget Overpricing