10.1002/hbm.22790 http://scihub22266oqcxt.onion/10.1002/hbm.22790 C4484811!4484811!25821110 free free free
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Hum+Brain+Mapp 2015 ; 36 (7): 2544-57 Nephropedia Template TP gab.com Text Twit Text FOAVip Twit Text # English Wikipedia
Sensation?to?cognition cortical streams in attention?deficit/hyperactivity disorder #MMPMID25821110Carmona S; Hoekzema E; Castellanos FX; García?García D; Lage?Castellanos A; Van Dijk KR; Navas?Sánchez FJ; Martínez K; Desco M; Sepulcre J Hum Brain Mapp 2015[Jul]; 36 (7): 2544-57 PMID25821110show ga
We sought to determine whether functional connectivity streams that link sensory, attentional, and higher?order cognitive circuits are atypical in attention?deficit/hyperactivity disorder (ADHD). We applied a graph?theory method to the resting?state functional magnetic resonance imaging data of 120 children with ADHD and 120 age?matched typically developing children (TDC). Starting in unimodal primary cortex?visual, auditory, and somatosensory?we used stepwise functional connectivity to calculate functional connectivity paths at discrete numbers of relay stations (or link?step distances). First, we characterized the functional connectivity streams that link sensory, attentional, and higher?order cognitive circuits in TDC and found that systems do not reach the level of integration achieved by adults. Second, we searched for stepwise functional connectivity differences between children with ADHD and TDC. We found that, at the initial steps of sensory functional connectivity streams, patients display significant enhancements of connectivity degree within neighboring areas of primary cortex, while connectivity to attention?regulatory areas is reduced. Third, at subsequent link?step distances from primary sensory cortex, children with ADHD show decreased connectivity to executive processing areas and increased degree of connections to default mode regions. Fourth, in examining medication histories in children with ADHD, we found that children medicated with psychostimulants present functional connectivity streams with higher degree of connectivity to regions subserving attentional and executive processes compared to medication?naïve children. We conclude that predominance of local sensory processing and lesser influx of information to attentional and executive regions may reduce the ability to organize and control the balance between external and internal sources of information in ADHD. Hum Brain Mapp 36:2544?2557, 2015. © 2015 Wiley Periodicals, Inc.Please enable JavaScript to view the comments powered by Disqus. ä DeepDyve Pubget Overpricing