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10.1007/s10875-013-9982-2 http://scihub22266oqcxt.onion/10.1007/s10875-013-9982-2 C4484798!4484798!24402620     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Immunol 2014 ; 34 (2): 260-4 Nephropedia Template TP {{tp|p=24402620|t=2014. Bone Density and Fractures in Autosomal Dominant Hyper IgE Syndrome |pdf=|usr=}}{{24402620}} gab.com Text Bone Density and Fractures in Autosomal Dominant Hyper IgE Syndrome JO: J Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24402620 #FOAvip Purpose: Autosomal Dominant Hyper IgE Recurrent Infection Syndrome (AD-HIES) is caused by mutations in STAT3 and characterized by eczema, recurrent bacterial infections, and skeletal and connective tissue abnormalities. To further understand the minimal trauma fractures of AD-HIES, we examined bone mineral density (BMD) and laboratory markers of bone turnover. Methods: Patients with AD-HIES enrolled in a prospective natural history study were examined with dual x-ray absorptiometry (DEXA) scans and laboratory studies of bone metabolism. The number of fractures was recorded as well as clinical features of AD-HIES including scoliosis and retained primary teeth. Patients on medications with skeletal effects, including bisphosphonates, were examined separately. Results: Twenty-three AD-HIES children (6?18 years) and 33 AD-HIES adults (21?50 years) not receiving bone-active drugs were studied. Fourteen of the 23 children (61 %) had histories of minimal trauma fractures, as did 26 of the 33 adults (79 %). Osteopenia or osteoporosis was found in 79% of children and adults. Only radial BMD correlated with the qualitative occurrence of fractures but it did not correlate with the numbers of fractures. Markers of bone metabolism did not correlate with minimal trauma fractures or BMD. Patients on bone-active medications had improved BMD, but still sustained fractures. Conclusions: Minimal trauma fractures and decreased BMD are common in AD-HIES. Low radial BMD is associated with fractures, but hip and spine BMD are not. Treatment with bisphosphonates increased BMD but its role in fracture prevention remains undefined. Twit Text FOAVip Bone Density and Fractures in Autosomal Dominant Hyper IgE Syndrome ????J Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24402620 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24402620 #FOAvip English Wikipedia <ref>{{Cite pmid|24402620}}</ref> Bone Density and Fractures in Autosomal Dominant Hyper IgE Syndrome #MMPMID24402620 Sowerwine KJ; Shaw PA; Gu W; Ling JC; Collins MT; Darnell DN; Anderson VL; Davis J; Hsu A; Welch P; Puck JM; Holland SM; Freeman AF J Clin Immunol 2014[Feb]; 34 (2): 260-4 PMID24402620show ga Purpose: Autosomal Dominant Hyper IgE Recurrent Infection Syndrome (AD-HIES) is caused by mutations in STAT3 and characterized by eczema, recurrent bacterial infections, and skeletal and connective tissue abnormalities. To further understand the minimal trauma fractures of AD-HIES, we examined bone mineral density (BMD) and laboratory markers of bone turnover. Methods: Patients with AD-HIES enrolled in a prospective natural history study were examined with dual x-ray absorptiometry (DEXA) scans and laboratory studies of bone metabolism. The number of fractures was recorded as well as clinical features of AD-HIES including scoliosis and retained primary teeth. Patients on medications with skeletal effects, including bisphosphonates, were examined separately. Results: Twenty-three AD-HIES children (6?18 years) and 33 AD-HIES adults (21?50 years) not receiving bone-active drugs were studied. Fourteen of the 23 children (61 %) had histories of minimal trauma fractures, as did 26 of the 33 adults (79 %). Osteopenia or osteoporosis was found in 79% of children and adults. Only radial BMD correlated with the qualitative occurrence of fractures but it did not correlate with the numbers of fractures. Markers of bone metabolism did not correlate with minimal trauma fractures or BMD. Patients on bone-active medications had improved BMD, but still sustained fractures. Conclusions: Minimal trauma fractures and decreased BMD are common in AD-HIES. Low radial BMD is associated with fractures, but hip and spine BMD are not. Treatment with bisphosphonates increased BMD but its role in fracture prevention remains undefined. äBone Density and Fractures in Autosomal Dominant Hyper IgE Syndrome (epmc).pdf DeepDyve Pubget Overpricing