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10.1016/j.tig.2011.06.009 http://scihub22266oqcxt.onion/10.1016/j.tig.2011.06.009 C4484734!4484734!21831473     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Genet 2011 ; 27 (10): 433-9 Nephropedia Template TP {{tp|p=21831473|t=2011. Noncoding RNAs and enhancers: complications of a long-distance relationship |pdf=|usr=}}{{21831473}} gab.com Text Noncoding RNAs and enhancers: complications of a long-distance relationship JO: Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=21831473 #FOAvip Spatial and temporal regulation of gene expression is achieved through instructions provided by the distal transcriptional regulatory elements known as enhancers. How enhancers transmit such information to their targets has been the subject of intense investigation. Recent advances in high throughput analysis of the mammalian transcriptome have revealed a surprising result indicating that a large number of enhancers are transcribed to noncoding RNAs. Although long noncoding RNAs were initially shown to confer epigenetic transcriptional repression, recent studies have uncovered a role for a class of such transcripts in gene-specific activation, often from distal genomic regions. In this review, we discuss recent findings on the role of long noncoding RNAs in transcriptional regulation, with an emphasis on new developments on the functional links between long noncoding RNAs and enhancers. Twit Text FOAVip Noncoding RNAs and enhancers: complications of a long-distance relationship ????Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=21831473 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21831473 #FOAvip English Wikipedia <ref>{{Cite pmid|21831473}}</ref> Noncoding RNAs and enhancers: complications of a long-distance relationship #MMPMID21831473 Ørom UA; Shiekhattar R Trends Genet 2011[Oct]; 27 (10): 433-9 PMID21831473show ga Spatial and temporal regulation of gene expression is achieved through instructions provided by the distal transcriptional regulatory elements known as enhancers. How enhancers transmit such information to their targets has been the subject of intense investigation. Recent advances in high throughput analysis of the mammalian transcriptome have revealed a surprising result indicating that a large number of enhancers are transcribed to noncoding RNAs. Although long noncoding RNAs were initially shown to confer epigenetic transcriptional repression, recent studies have uncovered a role for a class of such transcripts in gene-specific activation, often from distal genomic regions. In this review, we discuss recent findings on the role of long noncoding RNAs in transcriptional regulation, with an emphasis on new developments on the functional links between long noncoding RNAs and enhancers. äNoncoding RNAs and enhancers: complications of a long-distance relatio(epmc).pdf DeepDyve Pubget Overpricing