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10.2147/DDDT.S83288 http://scihub22266oqcxt.onion/10.2147/DDDT.S83288 C4484649!4484649!26150697     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Des+Devel+Ther 2015 ; 9 (ä): 3239-45 Nephropedia Template TP {{tp|p=26150697|t=2015. Sphingosine kinase 1 as an anticancer therapeutic target |pdf=|usr=}}{{26150697}} gab.com Text Sphingosine kinase 1 as an anticancer therapeutic target JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=26150697 #FOAvip The development of chemotherapeutic resistance is a major challenge in oncology. Elevated sphingosine kinase 1 (SK1) levels is predictive of a poor prognosis, and SK1 overexpression may confer resistance to chemotherapeutics. The SK/sphingosine-1-phosphate (S1P)/sphingosine-1-phosphate receptor (S1PR) signaling pathway has been implicated in the progression of various cancers and in chemotherapeutic drug resistance. Therefore, SK1 may represent an important target for cancer therapy. Targeting the SK/S1P/S1PR signaling pathway may be an effective anticancer therapeutic strategy, particularly in the context of overcoming drug resistance. This review summarizes our current understanding of the role of SK/S1P/S1PR signaling in cancer and development of SK1 inhibitors. Twit Text FOAVip Sphingosine kinase 1 as an anticancer therapeutic target ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=26150697 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26150697 #FOAvip English Wikipedia <ref>{{Cite pmid|26150697}}</ref> Sphingosine kinase 1 as an anticancer therapeutic target #MMPMID26150697 Gao Y; Gao F; Chen K; Tian Ml; Zhao Dl Drug Des Devel Ther 2015[]; 9 (ä): 3239-45 PMID26150697show ga The development of chemotherapeutic resistance is a major challenge in oncology. Elevated sphingosine kinase 1 (SK1) levels is predictive of a poor prognosis, and SK1 overexpression may confer resistance to chemotherapeutics. The SK/sphingosine-1-phosphate (S1P)/sphingosine-1-phosphate receptor (S1PR) signaling pathway has been implicated in the progression of various cancers and in chemotherapeutic drug resistance. Therefore, SK1 may represent an important target for cancer therapy. Targeting the SK/S1P/S1PR signaling pathway may be an effective anticancer therapeutic strategy, particularly in the context of overcoming drug resistance. This review summarizes our current understanding of the role of SK/S1P/S1PR signaling in cancer and development of SK1 inhibitors. äSphingosine kinase 1 as an anticancer therapeutic target (epmc).pdf DeepDyve Pubget Overpricing