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http://scihub22266oqcxt.onion/ C4484476!4484476!25869100     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (13): 11561-74 Nephropedia Template TP {{tp|p=25869100|t=2015. Inhibition of ?-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear ?-Catenin/TCF-1 complex: Critical role of STAT-3 |pdf=|usr=}}{{25869100}} gab.com Text Inhibition of -Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear -Catenin/TCF-1 complex: Critical role of STAT-3 JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25869100 #FOAvip Aberrant activation of ?-catenin/TCF signaling is related to the invasiveness of pancreatic cancer. In the present study, we evaluated the effect of capsaicin on ?-catenin/TCF signaling. In a concentration and time-dependent study, we observed that capsaicin treatment inhibits the activation of dishevelled (Dsh) protein DvI-1 in L3.6PL, PanC-1 and MiaPaCa-2 pancreatic cancer cells. Capsaicin treatment induced GSK-3? by inhibiting its phosphorylation and further activated APC and Axin multicomplex, leading to the proteasomal degradation of ?-catenin. Expression of TCF-1 and ?-catenin-responsive proteins, c-Myc and cyclin D1 also decreased in response to capsaicin treatment. Pre-treatment of cells with MG-132 blocked capsaicin-mediated proteasomal degradation of ?-catenin. To establish the involvement of ?-catenin in capsaicin-induced apoptosis, cells were treated with LiCl or SB415286, inhibitors of GSK-3?. Our results reveal that capsaicin treatment suppressed LiCl or SB415286-mediated activation of ?-catenin signaling. Our results further showed that capsaicin blocked nuclear translocation of ?-catenin, TCF-1 and p-STAT-3 (Tyr705). The immunoprecipitation results indicated that capsaicin treatment reduced the interaction of ?-catenin and TCF-1 in the nucleus. Moreover, capsaicin treatment significantly decreased the phosphorylation of STAT-3 at Tyr705. Interestingly, STAT-3 over expression or STAT-3 activation by IL-6, significantly increased the levels of ?-catenin and attenuated the effects of capsaicin in inhibiting ?-catenin signaling. Finally, capsaicin mediated inhibition of orthotopic tumor growth was associated with inhibition of ?-catenin/TCF-1 signaling. Taken together, our results suggest that capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of ?-catenin signaling due to the dissociation of ?-catenin/TCF-1 complex and the process was orchestrated by STAT-3. Twit Text FOAVip Inhibition of -Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear -Catenin/TCF-1 complex: Critical role of STAT-3 ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25869100 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25869100 #FOAvip English Wikipedia <ref>{{Cite pmid|25869100}}</ref> Inhibition of ?-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear ?-Catenin/TCF-1 complex: Critical role of STAT-3 #MMPMID25869100 Pramanik KC; Fofaria NM; Gupta P; Ranjan A; Kim SH; Srivastava SK Oncotarget 2015[May]; 6 (13): 11561-74 PMID25869100show ga Aberrant activation of ?-catenin/TCF signaling is related to the invasiveness of pancreatic cancer. In the present study, we evaluated the effect of capsaicin on ?-catenin/TCF signaling. In a concentration and time-dependent study, we observed that capsaicin treatment inhibits the activation of dishevelled (Dsh) protein DvI-1 in L3.6PL, PanC-1 and MiaPaCa-2 pancreatic cancer cells. Capsaicin treatment induced GSK-3? by inhibiting its phosphorylation and further activated APC and Axin multicomplex, leading to the proteasomal degradation of ?-catenin. Expression of TCF-1 and ?-catenin-responsive proteins, c-Myc and cyclin D1 also decreased in response to capsaicin treatment. Pre-treatment of cells with MG-132 blocked capsaicin-mediated proteasomal degradation of ?-catenin. To establish the involvement of ?-catenin in capsaicin-induced apoptosis, cells were treated with LiCl or SB415286, inhibitors of GSK-3?. Our results reveal that capsaicin treatment suppressed LiCl or SB415286-mediated activation of ?-catenin signaling. Our results further showed that capsaicin blocked nuclear translocation of ?-catenin, TCF-1 and p-STAT-3 (Tyr705). The immunoprecipitation results indicated that capsaicin treatment reduced the interaction of ?-catenin and TCF-1 in the nucleus. Moreover, capsaicin treatment significantly decreased the phosphorylation of STAT-3 at Tyr705. Interestingly, STAT-3 over expression or STAT-3 activation by IL-6, significantly increased the levels of ?-catenin and attenuated the effects of capsaicin in inhibiting ?-catenin signaling. Finally, capsaicin mediated inhibition of orthotopic tumor growth was associated with inhibition of ?-catenin/TCF-1 signaling. Taken together, our results suggest that capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of ?-catenin signaling due to the dissociation of ?-catenin/TCF-1 complex and the process was orchestrated by STAT-3. äInhibition of ?-Catenin signaling suppresses pancreatic tumor growth b(epmc).pdf DeepDyve Pubget Overpricing