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http://scihub22266oqcxt.onion/ C4484466!4484466!25823656     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25823656.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (13): 11421-33 Nephropedia Template TP {{tp|p=25823656|t=2015. Loss of ?-catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transition |pdf=|usr=}}{{25823656}} gab.com Text Loss of -catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transition JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25823656 #FOAvip Adrenal carcinoma (ACC) is a rare neoplasm with a poor outcome. Aberrant expression of ?-catenin has been found in approximatively 30% of ACC. We herein studied its effects on the growth of the human ACC cell line H295R. The cells were infected with short hairpin RNA (shRNA)-mediated silencing ?-catenin. Two shRNAs used induced down-regulation of ?-catenin protein levels. The expression of these shRNAs decreased cell growth and increased H295R cells in S and G2/M phases. This cytostatic effect is due to a decrease of phosphorylated MAPK and to an up-regulation expression of the cyclin-dependent kinase inhibitors p57KIP2, p21CIP and p27KIP1. In addition, the knockdown of ?-catenin decreased phosphorylated Akt and increased apoptosis. Finally, loss of ?-catenin was sufficient to induce the reversal of the epithelial-to-mesenchymal transition. We then transplanted these genetically modified H295R cells in Scid mice. Tumor growth suppression was achieved by the two shRNAs showing in vitro efficacy. Proliferation was not reduced in silenced tumors. In contrast, p57, p27 and p21 proteins were found expressed at high levels in silenced tumors along with an increase in apoptotic cells. These findings indicate that ?-catenin loss in H295R cells inhibits tumor growth by inducing transcriptional and functional changes. Twit Text FOAVip Loss of -catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transition ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25823656 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25823656 #FOAvip English Wikipedia <ref>{{Cite pmid|25823656}}</ref> Loss of ?-catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transition #MMPMID25823656 Salomon A; Keramidas M; Maisin C; Thomas M Oncotarget 2015[May]; 6 (13): 11421-33 PMID25823656show ga Adrenal carcinoma (ACC) is a rare neoplasm with a poor outcome. Aberrant expression of ?-catenin has been found in approximatively 30% of ACC. We herein studied its effects on the growth of the human ACC cell line H295R. The cells were infected with short hairpin RNA (shRNA)-mediated silencing ?-catenin. Two shRNAs used induced down-regulation of ?-catenin protein levels. The expression of these shRNAs decreased cell growth and increased H295R cells in S and G2/M phases. This cytostatic effect is due to a decrease of phosphorylated MAPK and to an up-regulation expression of the cyclin-dependent kinase inhibitors p57KIP2, p21CIP and p27KIP1. In addition, the knockdown of ?-catenin decreased phosphorylated Akt and increased apoptosis. Finally, loss of ?-catenin was sufficient to induce the reversal of the epithelial-to-mesenchymal transition. We then transplanted these genetically modified H295R cells in Scid mice. Tumor growth suppression was achieved by the two shRNAs showing in vitro efficacy. Proliferation was not reduced in silenced tumors. In contrast, p57, p27 and p21 proteins were found expressed at high levels in silenced tumors along with an increase in apoptotic cells. These findings indicate that ?-catenin loss in H295R cells inhibits tumor growth by inducing transcriptional and functional changes. äLoss of ?-catenin in adrenocortical cancer cells causes growth inhibit(epmc).pdf DeepDyve Pubget Overpricing