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2015 ; 6
(13
): 11009-22
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Leucine-rich ?-2-glycoprotein promotes TGF?1-mediated growth suppression in the
Lewis lung carcinoma cell lines
#MMPMID25826092
Takemoto N
; Serada S
; Fujimoto M
; Honda H
; Ohkawara T
; Takahashi T
; Nomura S
; Inohara H
; Naka T
Oncotarget
2015[May]; 6
(13
): 11009-22
PMID25826092
show ga
Leucine-rich ?2-glycoprotein (LRG) is an approximately 50-kDa glycoprotein that
has been found to be elevated in the sera of patients with several types of
cancer. LRG directly binds to transforming growth factor beta 1 (TGF?1) and
modulates TGF?1 signaling in endothelial cells; however, the precise function of
LRG in cancer remains unclear. This study aimed to investigate the role of LRG in
cancer. Lewis lung carcinoma (LLC) cells hardly expressed LRG. The growth of LLC
tumors allografted in the LRG knockout (KO) mice was significantly increased
compared with wild-type (WT) mice. Conversely, overexpression of LRG
significantly inhibited the growth of LLC tumors in WT mice. In the presence of
LRG, TGF?1 significantly inhibited the proliferation of LLC cells and human
hepatocellular carcinoma Hep3B cells in vitro by inducing apoptosis via the
potent activation of smad2 and its downstream signaling pathway. Furthermore,
administration of a TGF?R1 inhibitor (SB431542) significantly enhanced the growth
of LLC tumors in WT mice compared with LRG KO mice via inhibition of apoptosis.
We propose that LRG potentiates the effect of TGF?1 in cancer cells whose growth
is suppressed in the presence of TGF?1.
|*Apoptosis
[MESH]
|Animals
[MESH]
|Blotting, Western
[MESH]
|Carcinoma, Hepatocellular/genetics/pathology/*prevention & control
[MESH]
|Carcinoma, Lewis Lung/genetics/pathology/*prevention & control
[MESH]
|Cell Proliferation
[MESH]
|Female
[MESH]
|Glycoproteins/*physiology
[MESH]
|Humans
[MESH]
|Liver Neoplasms/genetics/pathology/*prevention & control
[MESH]
free
free
free
