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10.1038/srep11685 http://scihub22266oqcxt.onion/10.1038/srep11685 C4484407!4484407!26119962     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26119962|t=2015. The antimicrobial propeptide hCAP-18 plasma levels in neutropenia of various aetiologies: a prospective study |pdf=|usr=}}{{26119962}} gab.com Text The antimicrobial propeptide hCAP-18 plasma levels in neutropenia of various aetiologies: a prospective study JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26119962 #FOAvip The underlying cause of neutropenia may be difficult to determine due to similar clinical presentation in many neutropenic conditions. The neutrophil protein hCAP-18 (pro-LL-37) is a major component of neutrophil secondary granules and in this prospective study we assessed the use of hCAP-18 levels in blood plasma for differential diagnosis of neutropenic patients (n?=?133) of various aetiologies. Plasma levels of hCAP-18 were determined using immunoblot and ELISA. Patients with severe congenital neutropenia (n?=?23) presented with the lowest levels of plasma hCAP-18 and differential diagnostic accuracy revealed high sensitivity (100%) and specificity (98.8%) for hCAP-18 ELISA. The correlation coefficient of the hCAP-18 ELISA versus immunoblotting was (R?=?0.831) and that of the peptide LL-37 ELISA versus immunoblotting was (R?=?0.405) (P?<?0.001). Plasma hCAP-18 levels thus displayed high diagnostic value in differential diagnosis of chronic neutropenia. Neutropenic patients with Shwachman-Diamond syndrome, Barth syndrome, Cohen syndrome, acute myeloid leukaemia and specific granule deficiency presented with reduced plasma hCAP-18 levels as well. The blood plasma level of hCAP-18 was thus low in conditions in which the neutrophil antibacterial propeptide hCAP-18 is deficient, i.e. severe congenital neutropenia and neutrophil-specific granule deficiency, and in conditions in which bone marrow myelopoiesis is negatively affected. Twit Text FOAVip The antimicrobial propeptide hCAP-18 plasma levels in neutropenia of various aetiologies: a prospective study ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26119962 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26119962 #FOAvip English Wikipedia <ref>{{Cite pmid|26119962}}</ref> The antimicrobial propeptide hCAP-18 plasma levels in neutropenia of various aetiologies: a prospective study #MMPMID26119962 Ye Y; Carlsson G; Karlsson-Sjöberg JMT; Borregaard N; Modéer TU; Andersson ML; Pütsep KLA Sci Rep 2015[]; 5 (ä): ä PMID26119962show ga The underlying cause of neutropenia may be difficult to determine due to similar clinical presentation in many neutropenic conditions. The neutrophil protein hCAP-18 (pro-LL-37) is a major component of neutrophil secondary granules and in this prospective study we assessed the use of hCAP-18 levels in blood plasma for differential diagnosis of neutropenic patients (n?=?133) of various aetiologies. Plasma levels of hCAP-18 were determined using immunoblot and ELISA. Patients with severe congenital neutropenia (n?=?23) presented with the lowest levels of plasma hCAP-18 and differential diagnostic accuracy revealed high sensitivity (100%) and specificity (98.8%) for hCAP-18 ELISA. The correlation coefficient of the hCAP-18 ELISA versus immunoblotting was (R?=?0.831) and that of the peptide LL-37 ELISA versus immunoblotting was (R?=?0.405) (P? äThe antimicrobial propeptide hCAP-18 plasma levels in neutropenia of v(epmc).pdf DeepDyve Pubget Overpricing