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10.1038/srep11708 http://scihub22266oqcxt.onion/10.1038/srep11708 C4484370!4484370 !26118757     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26118757 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 11708 Nephropedia Template TP {{tp|p=26118757 |t=2015. Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus |pdf=|usr=}}{{26118757 }} gab.com Text Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26118757 #FOAvip The pathological hallmarks of Alzheimer's disease (AD) include amyloid beta (A?) accumulation, neurofibrillary tangle formation, synaptic dysfunction and neuronal loss. In this study, we investigated the neuroprotection of novel osmotin, a plant protein extracted from Nicotiana tabacum that has been considered to be a homolog of mammalian adiponectin. Here, we observed that treatment with osmotin (15 ?g/g, intraperitoneally, 4 hr) at 3 and 40 days post-intracerebroventricular injection of A?1-42 significantly ameliorated A?1-42-induced memory impairment in mice. These results revealed that osmotin reverses A?1-42 injection-induced synaptic deficits, A? accumulation and BACE-1 expression. Treatment with osmotin also alleviated the A?1-42-induced hyperphosphorylation of the tau protein at serine 413 through the regulation of the aberrant phosphorylation of p-PI3K, p-Akt (serine 473) and p-GSK3? (serine 9). Moreover, our western blots and immunohistochemical results indicated that osmotin prevented A?1-42-induced apoptosis and neurodegeneration in the A?1-42-treated mice. Furthermore, osmotin attenuated A?1-42-induced neurotoxicity in vitro.To our knowledge, this study is the first to investigate the neuroprotective effect of a novel osmotin against A?1-42-induced neurotoxicity. Our results demonstrated that this ubiquitous plant protein could potentially serve as a novel, promising, and accessible neuroprotective agent against progressive neurodegenerative diseases such as AD. Twit Text FOAVip Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26118757 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26118757 #FOAvip English Wikipedia <ref>{{Cite pmid|26118757 }}</ref> Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus #MMPMID26118757 Ali T ; Yoon GH ; Shah SA ; Lee HY ; Kim MO Sci Rep 2015[Jun]; 5 (ä): 11708 PMID26118757 show ga The pathological hallmarks of Alzheimer's disease (AD) include amyloid beta (A?) accumulation, neurofibrillary tangle formation, synaptic dysfunction and neuronal loss. In this study, we investigated the neuroprotection of novel osmotin, a plant protein extracted from Nicotiana tabacum that has been considered to be a homolog of mammalian adiponectin. Here, we observed that treatment with osmotin (15 ?g/g, intraperitoneally, 4 hr) at 3 and 40 days post-intracerebroventricular injection of A?1-42 significantly ameliorated A?1-42-induced memory impairment in mice. These results revealed that osmotin reverses A?1-42 injection-induced synaptic deficits, A? accumulation and BACE-1 expression. Treatment with osmotin also alleviated the A?1-42-induced hyperphosphorylation of the tau protein at serine 413 through the regulation of the aberrant phosphorylation of p-PI3K, p-Akt (serine 473) and p-GSK3? (serine 9). Moreover, our western blots and immunohistochemical results indicated that osmotin prevented A?1-42-induced apoptosis and neurodegeneration in the A?1-42-treated mice. Furthermore, osmotin attenuated A?1-42-induced neurotoxicity in vitro.To our knowledge, this study is the first to investigate the neuroprotective effect of a novel osmotin against A?1-42-induced neurotoxicity. Our results demonstrated that this ubiquitous plant protein could potentially serve as a novel, promising, and accessible neuroprotective agent against progressive neurodegenerative diseases such as AD. |Amyloid beta-Peptides/*toxicity [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Aspartic Acid Endopeptidases/metabolism [MESH] |Behavior, Animal [MESH] |Glycogen Synthase Kinase 3 beta [MESH] |Glycogen Synthase Kinase 3/metabolism [MESH] |Hippocampus/drug effects/metabolism/*pathology [MESH] |Male [MESH] |Memory Disorders/complications/*drug therapy/pathology [MESH] |Mice, Inbred C57BL [MESH] |Neurodegenerative Diseases/complications/*drug therapy/pathology [MESH] |Neurotoxins/toxicity [MESH] |Phosphatidylinositol 3-Kinases/metabolism [MESH] |Phosphorylation/drug effects [MESH] |Plant Proteins/pharmacology/*therapeutic use [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Signal Transduction/drug effects [MESH] |Synapses/drug effects/pathology [MESH]Osmotin attenuates amyloid beta-induced memory impairment, tau phospho(epmc).pdf DeepDyve Pubget Overpricing