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10.3389/fimmu.2015.00337

http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00337
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C4484338!4484338!26175733
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suck abstract from ncbi


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pmid26175733      Front+Immunol 2015 ; 6 (ä): ä
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  • Role of Group 1 CD1-Restricted T Cells in Infectious Disease #MMPMID26175733
  • Siddiqui S; Visvabharathy L; Wang CR
  • Front Immunol 2015[]; 6 (ä): ä PMID26175733show ga
  • The evolutionarily conserved CD1 family of antigen-presenting molecules presents lipid antigens rather than peptide antigens to T cells. CD1 molecules, unlike classical MHC molecules, display limited polymorphism, making CD1-restricted lipid antigens attractive vaccine targets that could be recognized in a genetically diverse human population. Group 1 CD1 (CD1a, CD1b, and CD1c)-restricted T cells have been implicated to play critical roles in a variety of autoimmune and infectious diseases. In this review, we summarize current knowledge and recent discoveries on the development of group 1 CD1-restricted T cells and their function in different infection models. In particular, we focus on (1) newly identified microbial and self-lipid antigens, (2) kinetics, phenotype, and unique properties of group 1 CD1-restricted T cells during infection, and (3) the similarities of group 1 CD1-restricted T cells to the closely related group 2 CD1-restricted T cells.
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