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10.1136/thoraxjnl-2014-206680 http://scihub22266oqcxt.onion/10.1136/thoraxjnl-2014-206680 C4484044!4484044!25903964     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Thorax 2015 ; 70 (7): 617-24 Nephropedia Template TP {{tp|p=25903964|t=2015. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS) |pdf=|usr=}}{{25903964}} gab.com Text Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS) JO: Thorax http://www.kidney.de/pget.php?&tw=1&pmid=25903964 #FOAvip Rationale: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory distress syndrome (ARDS). Causality of these associations has never been demonstrated. Objectives: To determine if ARDS is associated with vitamin D deficiency in a clinical setting and to determine if vitamin D deficiency in experimental models of ARDS influences its severity. Methods: Human, murine and in vitro primary alveolar epithelial cell work were included in this study. Findings: Vitamin D deficiency (plasma 25(OH)D levels <50?nmol/L) was ubiquitous in patients with ARDS and present in the vast majority of patients at risk of developing ARDS following oesophagectomy. In a murine model of intratracheal lipopolysaccharide challenge, dietary-induced vitamin D deficiency resulted in exaggerated alveolar inflammation, epithelial damage and hypoxia. In vitro, vitamin D has trophic effects on primary human alveolar epithelial cells affecting >600 genes. In a clinical setting, pharmacological repletion of vitamin D prior to oesophagectomy reduced the observed changes of in vivo measurements of alveolar capillary damage seen in deficient patients. Conclusions: Vitamin D deficiency is common in people who develop ARDS. This deficiency of vitamin D appears to contribute to the development of the condition, and approaches to correct vitamin D deficiency in patients at risk of ARDS should be developed. Trial registration: UKCRN ID 11994. Twit Text FOAVip Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS) ????Thorax http://www.kidney.de/pget.php?&tw=1&pmid=25903964 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25903964 #FOAvip English Wikipedia <ref>{{Cite pmid|25903964}}</ref> Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS) #MMPMID25903964 Dancer RCA; Parekh D; Lax S; D'Souza V; Zheng S; Bassford CR; Park D; Bartis DG; Mahida R; Turner AM; Sapey E; Wei W; Naidu B; Stewart PM; Fraser WD; Christopher KB; Cooper MS; Gao F; Sansom DM; Martineau AR; Perkins GD; Thickett DR Thorax 2015[Jul]; 70 (7): 617-24 PMID25903964show ga Rationale: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory distress syndrome (ARDS). Causality of these associations has never been demonstrated. Objectives: To determine if ARDS is associated with vitamin D deficiency in a clinical setting and to determine if vitamin D deficiency in experimental models of ARDS influences its severity. Methods: Human, murine and in vitro primary alveolar epithelial cell work were included in this study. Findings: Vitamin D deficiency (plasma 25(OH)D levels <50?nmol/L) was ubiquitous in patients with ARDS and present in the vast majority of patients at risk of developing ARDS following oesophagectomy. In a murine model of intratracheal lipopolysaccharide challenge, dietary-induced vitamin D deficiency resulted in exaggerated alveolar inflammation, epithelial damage and hypoxia. In vitro, vitamin D has trophic effects on primary human alveolar epithelial cells affecting >600 genes. In a clinical setting, pharmacological repletion of vitamin D prior to oesophagectomy reduced the observed changes of in vivo measurements of alveolar capillary damage seen in deficient patients. Conclusions: Vitamin D deficiency is common in people who develop ARDS. This deficiency of vitamin D appears to contribute to the development of the condition, and approaches to correct vitamin D deficiency in patients at risk of ARDS should be developed. Trial registration: UKCRN ID 11994. äVitamin D deficiency contributes directly to the acute respiratory dis(epmc).pdf DeepDyve Pubget Overpricing