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http://scihub22266oqcxt.onion/ C4484028!4484028 !26131086     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26131086 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Clin+Exp+Med 2015 ; 8 (4 ): 5129-36 Nephropedia Template TP {{tp|p=26131086 |t=2015. Effects of Jiangya Xiaoke prescription on TGF-?1 in diabetic nephropathy rats with hypertension and its mechanisms |pdf=|usr=}}{{26131086 }} gab.com Text Effects of Jiangya Xiaoke prescription on TGF- 1 in diabetic nephropathy rats with hypertension and its mechanisms JO: Int J Clin Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26131086 #FOAvip OBJECTIVE: To observe the effects of Jiangya Xiaoke prescription on transforming growth factor-?1 (TGF-?1) in diabetic nephropathy (DN) with hypertension rats and to investigate its mechanisms. METHODS: DN with hypertension models were made by 4 weeks high-salt diet with high sugar and fat for male Wistar rats, and intraperitoneal injection of streptozotocin (STZ). The model rats were randomly divided into three groups: untreated model group (n = 15); metformin group (n = 15), orally given metformin; Prescription group (n = 15), orally administrated JXR, for 8 weeks respectively. Blood pressure was measured before modeling and after treatment of 2, 4, 8 weeks. Fasting blood glucose (FBG), total triglyceride (TG) and total cholesterol (TC) and urine albumin excretion (UAE) of rats were observed and recorded. Renal histomorphology with PAS staining was observed by the light microscope. TGF-?1 in kidney was detected by immunohistochemical assay and TGF-?1 mRNA in renal cortex was detected by RT-PCR. RESULTS: The base blood pressure of rats has no significant difference before modeling (P > 0.05). After 4 weeks of treatment, compared with model group, blood pressure in metformin group decreased (P < 0.01), blood pressure in Jiangya Xiaoke prescription group was slightly lower (P < 0.05). When 8 weeks, the rebound of blood pressure in metformin group is appropriate with the model, the blood pressure of Jiangya Xiaoke prescription reduced significantly (P < 0.01). Compared with model group, FBG, UAE and TG in Jiangya Xiaoke prescription group and metformin group significantly decreased (P < 0.01), TC levels also decreased (P < 0.05). The level of TGF-?1 in Jiangya Xiaoke prescription group and the metformin group decreased (P < 0.01), and level of TGF-?1 in Jiangya Xiaoke prescription group was lower significantly than that in metformin group (P < 0.05). The mRNA expression of TGF-?1 in Jiangya Xiaoke prescription group and the metformin group was significantly lower than model group (P < 0.01). Pathological changes were ameliorated in Jiangya Xiaoke prescription and metformin group compared with model group. CONCLUSION: Jiangya Xiaoke prescription can regulate blood pressure and improve renal functional morphology through down-regulation of TGF-?1 and its mRNA expression in DN rats with hypertension. We initially proved that the inhibition effect of TGF-?1 in Jiangya Xiaoke prescription is better than metformin, and Jiangya Xiaoke prescription can lower blood pressure to normal levels with a better step-down smoothly and a long-term efficacy. Twit Text FOAVip Effects of Jiangya Xiaoke prescription on TGF- 1 in diabetic nephropathy rats with hypertension and its mechanisms ????Int J Clin Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26131086 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26131086 #FOAvip English Wikipedia <ref>{{Cite pmid|26131086 }}</ref> Effects of Jiangya Xiaoke prescription on TGF-?1 in diabetic nephropathy rats with hypertension and its mechanisms #MMPMID26131086 Xie S ; Lu K ; Zhang Y ; Song X ; Tan M ; Wang C Int J Clin Exp Med 2015[]; 8 (4 ): 5129-36 PMID26131086 show ga OBJECTIVE: To observe the effects of Jiangya Xiaoke prescription on transforming growth factor-?1 (TGF-?1) in diabetic nephropathy (DN) with hypertension rats and to investigate its mechanisms. METHODS: DN with hypertension models were made by 4 weeks high-salt diet with high sugar and fat for male Wistar rats, and intraperitoneal injection of streptozotocin (STZ). The model rats were randomly divided into three groups: untreated model group (n = 15); metformin group (n = 15), orally given metformin; Prescription group (n = 15), orally administrated JXR, for 8 weeks respectively. Blood pressure was measured before modeling and after treatment of 2, 4, 8 weeks. Fasting blood glucose (FBG), total triglyceride (TG) and total cholesterol (TC) and urine albumin excretion (UAE) of rats were observed and recorded. Renal histomorphology with PAS staining was observed by the light microscope. TGF-?1 in kidney was detected by immunohistochemical assay and TGF-?1 mRNA in renal cortex was detected by RT-PCR. RESULTS: The base blood pressure of rats has no significant difference before modeling (P > 0.05). After 4 weeks of treatment, compared with model group, blood pressure in metformin group decreased (P < 0.01), blood pressure in Jiangya Xiaoke prescription group was slightly lower (P < 0.05). When 8 weeks, the rebound of blood pressure in metformin group is appropriate with the model, the blood pressure of Jiangya Xiaoke prescription reduced significantly (P < 0.01). Compared with model group, FBG, UAE and TG in Jiangya Xiaoke prescription group and metformin group significantly decreased (P < 0.01), TC levels also decreased (P < 0.05). The level of TGF-?1 in Jiangya Xiaoke prescription group and the metformin group decreased (P < 0.01), and level of TGF-?1 in Jiangya Xiaoke prescription group was lower significantly than that in metformin group (P < 0.05). The mRNA expression of TGF-?1 in Jiangya Xiaoke prescription group and the metformin group was significantly lower than model group (P < 0.01). Pathological changes were ameliorated in Jiangya Xiaoke prescription and metformin group compared with model group. CONCLUSION: Jiangya Xiaoke prescription can regulate blood pressure and improve renal functional morphology through down-regulation of TGF-?1 and its mRNA expression in DN rats with hypertension. We initially proved that the inhibition effect of TGF-?1 in Jiangya Xiaoke prescription is better than metformin, and Jiangya Xiaoke prescription can lower blood pressure to normal levels with a better step-down smoothly and a long-term efficacy. äEffects of Jiangya Xiaoke prescription on TGF-?1 in diabetic nephropat(epmc).pdf DeepDyve Pubget Overpricing