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Analgesic effects of melatonin on post-herpetic neuralgia #MMPMID26131073
Deng YK; Ding JF; Liu J; Yang YY
Int J Clin Exp Med 2015[]; 8 (4): 5004-9 PMID26131073show ga
Objective: This study aims to explore the analgesic effects of melatonin on post-herpetic neuralgia and its possible mechanism. Methods: A total of 48 PHN Wistar rats were divided into 4 groups randomly: Normal, PHN, PHN+MT and naloxone, 4P-PDOT or L-arginine+120 mg/kg MT (C). Heat pain latency was determined after MT injection for 20 min, 40 min, 80 min and 120 min respectively. The expression levels of ? receptor and MT2 receptor in different tissues of rats were detected by RT-PCR method. NO content was determined. Results: Heat pain latency in PHN rats were lower than that of control group (P<0.05), MT could increase the heat pain latency with dose-dependent, while naloxone, 4P-PDOT and L-arginine could reverse the analgesic effect of MT (P<0.05). The expression levels of ? receptor and MT2 receptor in spinal cord, hypothalamus and hippocampus in PHN+MT (120 mg/kg, i. p.) group were significantly higher than that of PHN group (P<0.05). The NO levels in the brain and spinal cord tissues in PHN group were higher than that of PHN+MT (120 mg/kg) group (P<0.05). Conclusions: MT had significant analgesic effects in the treatment of PHN, and its mechanism was closely related with ?opioid receptor, NO and MT2 receptor.