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2015 ; 8
(4
): 4846-54
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Effectiveness and risk associated with infliximab alone and in combination with
immunosuppressors for Crohn s disease: a systematic review and meta-analysis
#MMPMID26131059
Wang Z
; Wang J
; Fu L
; Dong S
; Ge Y
; Zhang J
; Huang B
; Wang Q
; Wang Z
Int J Clin Exp Med
2015[]; 8
(4
): 4846-54
PMID26131059
show ga
OBJECTIVE: Infliximab (IFX) monotherapy and IFX combined with immunosuppressors
have been used in the treatment of Crohn's disease. However, the differences
between combination therapy and IFX alone remain controversial. The aim of this
meta-analysis was to evaluate the effectiveness and risk associated with
combination therapy and IFX monotherapy. METHODS: Systematic searches were
performed for randomized controlled trials with PubMed, Web of Science, OVID, and
the Cochrane Library. The analyzed contents included induction of remission,
short-term maintenance of remission, long-term maintenance of remission, and
risks. The final results were estimated using statistical data of odds ratio
(OR), relevant 95% confidence interval (CI), and P value. RESULTS: 6 out of 1041
citations met the selection criteria. There was no statistical difference in the
effectiveness of induction and long-term maintenance of remission between two
groups (P=0.07, 0.12). However, for short-term maintenance of remission, there
was mild statistical difference between two groups (P=0.02, OR=1.66). For risks,
apart from the difference in the aspect of reaction to infusion (OR=0.43, 95%
CI=0.29-0.65, P<0.0001), there was no statistical difference. CONCLUSIONS: There
was no significant difference in effectiveness and risks between the therapy
groups. However, these outcomes should be interpreted with caution. Specific
categories of combination therapy and periodic medication should be paid more
attention in future studies.