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http://scihub22266oqcxt.onion/ C4483937!4483937!26131103     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Clin+Exp+Med 2015 ; 8 (4): 5287-94 Nephropedia Template TP {{tp|p=26131103|t=2015. Alkannin inhibits growth and invasion of glioma cells C6 through IQGAP/mTOR signal pathway |pdf=|usr=}}{{26131103}} gab.com Text Alkannin inhibits growth and invasion of glioma cells C6 through IQGAP/mTOR signal pathway JO: Int J Clin Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26131103 #FOAvip Objective: This study aims to explore the effect of alkannin on the growth and invasion of glioma cells and its mechanism. Methods: The effects of alkannin on the growth and invasion of glioma cells were detected with MTT assay, clone forming test and transwell assay. The effects of alkannin on the cell cycle were detected with flow cytometry assay. The changes of cyclin, MMPs and IQGAP/mTOR signal pathway related proteins were detected with western blotting methods. Results: Alkannin (1 ?M, 3 ?M and 10 ?M) can significantly inhibit the growth, proliferation, migration and invasion of glioma cells C6 with dose dependent. Alkannin can block cell cycle in G1 phase with the increased concentration, which was related with the down-regulation of cyclinA1, cyclinA2 and cyclinD1 expression. Alkannin can also down-regulate the expression of MMP 2, MMP 9 and IQGAP. Alkannin has no effect on mTOR but can inhibit the phosphorylation of mTOR. Conclusions: Alkannin can inhibit the growth and invasion of glioma cells C6 through IQGAP/mTOR signal pathway. Twit Text FOAVip Alkannin inhibits growth and invasion of glioma cells C6 through IQGAP/mTOR signal pathway ????Int J Clin Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=26131103 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26131103 #FOAvip English Wikipedia <ref>{{Cite pmid|26131103}}</ref> Alkannin inhibits growth and invasion of glioma cells C6 through IQGAP/mTOR signal pathway #MMPMID26131103 Gao C; Liang C; Nie Z; Liu Y; Wang J; Zhang D Int J Clin Exp Med 2015[]; 8 (4): 5287-94 PMID26131103show ga Objective: This study aims to explore the effect of alkannin on the growth and invasion of glioma cells and its mechanism. Methods: The effects of alkannin on the growth and invasion of glioma cells were detected with MTT assay, clone forming test and transwell assay. The effects of alkannin on the cell cycle were detected with flow cytometry assay. The changes of cyclin, MMPs and IQGAP/mTOR signal pathway related proteins were detected with western blotting methods. Results: Alkannin (1 ?M, 3 ?M and 10 ?M) can significantly inhibit the growth, proliferation, migration and invasion of glioma cells C6 with dose dependent. Alkannin can block cell cycle in G1 phase with the increased concentration, which was related with the down-regulation of cyclinA1, cyclinA2 and cyclinD1 expression. Alkannin can also down-regulate the expression of MMP 2, MMP 9 and IQGAP. Alkannin has no effect on mTOR but can inhibit the phosphorylation of mTOR. Conclusions: Alkannin can inhibit the growth and invasion of glioma cells C6 through IQGAP/mTOR signal pathway. äAlkannin inhibits growth and invasion of glioma cells C6 through IQGAP(epmc).pdf DeepDyve Pubget Overpricing