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2015 ; 8
(4
): 5954-8
Nephropedia Template TP
gab.com Text
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English Wikipedia
RhoBTB2 (DBC2) functions as a multifunctional tumor suppressor in thyroid cancer
cells via mitochondrial apoptotic pathway
#MMPMID26131191
Wang CJ
; Yang D
; Luo YW
Int J Clin Exp Med
2015[]; 8
(4
): 5954-8
PMID26131191
show ga
Thyroid cancer is the most common endocrine malignancy worldwide. Tumor
suppressor gene RhoBTB2 (also known as Deleted in Breast Cancer 2, DBC2) was
observed in various carcinomas, however, no reports showed the effects of RhoBTB2
on thyroid cancer. In our study, we found that RhoBTB2 decreases proliferation,
increases apoptosis, inhibits mobility, and induces mitochondria damage in SW579
cells through increased Bax and decreased Bcl-2 and Bcl-xL protein expression.
The effects of RhoBTB2 on SW579 cells were inversed by using butin (an inhibitor
of the mitochondrial apoptosis pathway). Our results suggest that RhoBTB2
suppresses the growth of SW579 cells through a mitochondrial apoptosis pathway.