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2015 ; 8
(4
): 5499-505
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LncRNA MALAT1 overexpression is an unfavorable prognostic factor in human cancer:
evidence from a meta-analysis
#MMPMID26131129
Zhang J
; Zhang B
; Wang T
; Wang H
Int J Clin Exp Med
2015[]; 8
(4
): 5499-505
PMID26131129
show ga
Long non-coding RNAs (lncRNAs) have been suggested to serve as an important role
in tumor development and progression. The aim of this study was to analyse the
association between lncRNA metastasis-associated lung adenocarcinoma transcript 1
(MALAT1) and cancer patients' overall survival. We systematically and carefully
searched the studies from electronic databases and seriously identified according
to eligibility criteria. The correlation between lncRNA MALAT1 expression and
overall survival in human cancers was evaluated through Review Manager. A total
of 8 studies which included 792 cancer patients were included in the final
analysis. Meta-analysis showed that lncRNA MALAT1 overexpression was correlated
with a poor overall survival and the pooled hazard ratio (HR) and corresponding
95% confidence interval (CI) was 1.94 (95% CI 1.59-2.38). From subgroup analyses,
we present evidence that lncRNA MALAT1 overexpression was an unfavorable
prognostic factor for patients' overall survival in non-small cell lung cancer
and pancreatic cancer, the pooled HRs (95% CI) were 1.86 (95% CI 1.27-2.73) and
1.78 (95% CI 1.30-2.44), respectively. In conclusion, lncRNA MALAT1 is a
potential prognostic factor in human cancers.