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2015 ; 8
(4
): 6530-43
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Probiotics improve efficacy and tolerability of triple therapy to eradicate
Helicobacter pylori: a meta-analysis of randomized controlled trials
#MMPMID26131283
Gong Y
; Li Y
; Sun Q
Int J Clin Exp Med
2015[]; 8
(4
): 6530-43
PMID26131283
show ga
OBJECTIVE: Gastric colonization by Helicobacter pylori is linked to a host of
diseases, but eradication rates have declined in recent years. Some experimental
studies suggest that probiotics may inhibit growth of H. pylori. This
investigation was conducted to assess the impact of probiotics on both efficacy
and tolerability of triple therapy to eradicate H. pylori. METHODS: PubMed, Web
of Science, and the Cochrane Collaboration were searched for relevant articles
published through August 31, 2014. All analytics relied on commercially available
software (Stata 11). RESULTS: Twenty-three studies (N = 3900) qualified for
meta-analysis. Pooled H. pylori eradication rates for triple therapy used alone
and with added probiotics were 1464/2026 (72.26%; 95% CI, 67.66%-74.13) and
1513/1874 (80.74%; 95% CI, 74.68%-82.76%), respectively (odds ratio [OR] = 0.58;
95% CI, 0.50-0.68). Loss of appetite was similar in both groups (OR = 0.94; 95%
CI, 0.61-1.45), but most adverse events (nausea, diarrhea, epigastric pain,
vomiting, taste distortion, and skin rash) were mitigated through addition of
probiotics. Publication bias was not evident, as indicated by Begg's and Egger's
tests. CONCLUSIONS: Probiotics may improve the efficacy of triple therapy in
eradicating gastric H. pylori and alleviate most treatment-related adverse
events.