Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26131286
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26131286
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Clin+Exp+Med
2015 ; 8
(4
): 6563-7
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Effectiveness of inhibitor rapamycin, saracatinib, linsitinib and JNJ-38877605
against human prostate cancer cells
#MMPMID26131286
Li W
; Wang Z
; Wang L
; He X
; Wang G
; Liu H
; Guo F
; Wang Z
; Chen G
Int J Clin Exp Med
2015[]; 8
(4
): 6563-7
PMID26131286
show ga
To investigate the effect of different concentrations of inhibitors rapamycin,
saracatinib, linsitinib and JNJ-38877605 on PC-3 cells with CCK-8 assay,
respectively. PC-3 cells were incubated with different concentrations of
rapamycin, saracatinib, linsitinib and JNJ-38877605, respectively, for 48 h at
37°C, the concentrations of rapamycin were 5 nM, 10 nM, 20 nM, 50 nM, 75 nM, 100
nM; Saracatinib: 0.125 nM, 0.25 nM, 0.5 nM, 1 nM, 2.5 nM, 5 nM; Linsitinib: 2 nM,
5 nM, 10 nM, 20 nM, 40 nM, 60 nM; JNJ-38877605: 0.125 nM, 0.5 nM, 1 nM, 2.5 nM, 5
nM, 10 nM. The proliferation of PC-3 cells was examined by CCK-8. Different
concentrations of inhibitor rapamycin remarkably inhibited PC-3 cell
proliferation after 48 h (P<0.05), inhibitory action did not change significantly
from 5 nM-100 nM; different concentrations of saracatinib, linsitinib and
JNJ-38877605 did not inhibit PC-3 cell proliferation after 48 h. Rapamycin
treatment at low concentration can inhibit the proliferation of PC-3 cells, while
saracatinib, linsitinib and JNJ-38877605 do not inhibit PC-3 cell proliferation.