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2015 ; 8
(4
): 6388-96
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Simvastatin ameliorates low-dose streptozotocin-induced type 2 diabetic
nephropathy in an experimental rat model
#MMPMID26131264
Zhang S
; Xu H
; Yu X
; Wang Y
; Sun F
; Sui D
Int J Clin Exp Med
2015[]; 8
(4
): 6388-96
PMID26131264
show ga
The present study aims to study the possible renal protective effect of
simvastatin in the development and progression of type 2 diabetic nephropathy. A
rat model of T2DN was induced by high-fat diet together with single low-dose of
streptozotocin. The diabetic rats were either given treatment or vehicle control
for 13 weeks to develop nephropathy. At the end of treatment, parameters of renal
function were determined. Kidney samples were collected for histological studies
and generated homogenates for biochemical analysis. In T2DN rats, severe
hyperglycemia was developed, FBG were markedly elevated. Diabetes induced
significant alterations in renal structure, such as severe reduction of
glomerular tufts, increase in Bowman's spaces, thickening of GBM. In addition,
and SCr, UAER and BUN are elevated, accompanied with reduction in UCr and CCr,
indicating obvious renal failure. On the other hand, endogenous antioxidants SOD,
GSH-Px were reduced, whereas MDA was increased. However, treatment of T2DN rats
with simvastatin restored renal changes in different aspects. Our results showed
that STZ-induced T2DN could be attenuated by simvastatin. The renoprotective
effects of simvastatin was indicated by improvements in kidney function
parameters, and was attributed by its lipid-lowering effect as well as its
anti-oxidative stress, anti-inflammatory properties without having noticeable
influence on glycemic control. Simvastatin ameliorates low-dose
Streptozotocin-induced type 2 diabetic nephropathy in an experimental rat model.
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