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The Relationship between Anemia and the Initiation of Dialysis in Patients with
Type 2 Diabetic Nephropathy
#MMPMID26124994
Kim SH
; Lee KA
; Jin HY
; Baek HS
; Park TS
Diabetes Metab J
2015[Jun]; 39
(3
): 240-6
PMID26124994
show ga
BACKGROUND: Anemia is associated with various poor clinical outcomes in chronic
kidney disease patients. The aim of this study was to investigate the
relationship between anemia and the initiation degree and time of dialysis in
type 2 diabetic nephropathy patients. METHODS: This observational retrospective
study included 130 type 2 diabetic nephropathy patients in Korea. The existence
of anemia, the degree and time of dialysis initiation were reviewed. Clinical
characteristics and variables were also compared. RESULTS: The levels of
hemoglobin and serum creatinine were significantly correlated with the dialysis
initiation (P<0.05) during the 10-year follow-up period. Patients with anemia
showed rapid decline of renal function, causing significantly more dialysis
initiation (54.1% vs. 5.4%, P<0.05) compare to the patients without anemia.
Average time to initiate dialysis in patients with anemia was 45.1 months (range,
8.0 to 115.8 months), which was significantly faster than that (68.3 months
[range, 23.3 to 108.8 months]) in patients without anemia (P<0.01). The risk to
dialysis initiation was significantly increased in patients with anemia compared
to the patients without anemia (adjusted hazard ratio, 8.1; 95% confidence
interval, 2.4 to 27.0; P<0.05). CONCLUSION: Anemia is associated with rapid
decline of renal dysfunction and faster initiation of dialysis in diabetic
nephropathy patients. Therefore, clinicians should pay an earlier attention to
anemia during the management of diabetes.
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