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10.4093/dmj.2015.39.3.188 http://scihub22266oqcxt.onion/10.4093/dmj.2015.39.3.188 C4483603!4483603!26124988     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes+Metab+J 2015 ; 39 (3): 188-97 Nephropedia Template TP {{tp|p=26124988|t=2015. Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers |pdf=|usr=}}{{26124988}} gab.com Text Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers JO: Diabetes Metab J http://www.kidney.de/pget.php?&tw=1&pmid=26124988 #FOAvip Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major regulatory step, an irreversible reaction of oxidative decarboxylation of pyruvate to acetyl-CoA. Tight control of PDC is critical because it plays a key role in glucose disposal. PDC activity is tightly regulated using phosphorylation by pyruvate dehydrogenase kinases (PDK1 to 4) and pyruvate dehydrogenase phosphatases (PDP1 and 2). PDKs and PDPs exhibit unique tissue expression patterns, kinetic properties, and sensitivities to regulatory molecules. During the last decades, the up-regulation of PDKs has been observed in the tissues of patients and mammals with metabolic diseases, which suggests that the inhibition of these kinases may have beneficial effects for treating metabolic diseases. This review summarizes the recent advances in the role of specific PDK isoenzymes on the induction of metabolic diseases and describes the effects of PDK inhibition on the prevention of metabolic diseases using pharmacological inhibitors. Based on these reports, PDK isoenzymes are strong therapeutic targets for preventing and treating metabolic diseases. Twit Text FOAVip Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers ????Diabetes Metab J http://www.kidney.de/pget.php?&tw=1&pmid=26124988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26124988 #FOAvip English Wikipedia <ref>{{Cite pmid|26124988}}</ref> Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers #MMPMID26124988 Jeoung NH Diabetes Metab J 2015[Jun]; 39 (3): 188-97 PMID26124988show ga Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major regulatory step, an irreversible reaction of oxidative decarboxylation of pyruvate to acetyl-CoA. Tight control of PDC is critical because it plays a key role in glucose disposal. PDC activity is tightly regulated using phosphorylation by pyruvate dehydrogenase kinases (PDK1 to 4) and pyruvate dehydrogenase phosphatases (PDP1 and 2). PDKs and PDPs exhibit unique tissue expression patterns, kinetic properties, and sensitivities to regulatory molecules. During the last decades, the up-regulation of PDKs has been observed in the tissues of patients and mammals with metabolic diseases, which suggests that the inhibition of these kinases may have beneficial effects for treating metabolic diseases. This review summarizes the recent advances in the role of specific PDK isoenzymes on the induction of metabolic diseases and describes the effects of PDK inhibition on the prevention of metabolic diseases using pharmacological inhibitors. Based on these reports, PDK isoenzymes are strong therapeutic targets for preventing and treating metabolic diseases. äPyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and C(epmc).pdf DeepDyve Pubget Overpricing