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10.1681/ASN.2013060634 http://scihub22266oqcxt.onion/10.1681/ASN.2013060634 C4483573!4483573 !25349206     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25349206 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Nephrol 2015 ; 26 (7 ): 1537-48 Nephropedia Template TP {{tp|p=25349206 |t=2015. Hypertrophy in the Distal Convoluted Tubule of an 11?-Hydroxysteroid Dehydrogenase Type 2 Knockout Model |pdf=|usr=}}{{25349206 }} gab.com Text Hypertrophy in the Distal Convoluted Tubule of an 11 -Hydroxysteroid Dehydrogenase Type 2 Knockout Model JO: J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25349206 #FOAvip Na(+) transport in the renal distal convoluted tubule (DCT) by the thiazide-sensitive NaCl cotransporter (NCC) is a major determinant of total body Na(+) and BP. NCC-mediated transport is stimulated by aldosterone, the dominant regulator of chronic Na(+) homeostasis, but the mechanism is controversial. Transport may also be affected by epithelial remodeling, which occurs in the DCT in response to chronic perturbations in electrolyte homeostasis. Hsd11b2(-/-) mice, which lack the enzyme 11?-hydroxysteroid dehydrogenase type 2 (11?HSD2) and thus exhibit the syndrome of apparent mineralocorticoid excess, provided an ideal model in which to investigate the potential for DCT hypertrophy to contribute to Na(+) retention in a hypertensive condition. The DCTs of Hsd11b2(-/-) mice exhibited hypertrophy and hyperplasia and the kidneys expressed higher levels of total and phosphorylated NCC compared with those of wild-type mice. However, the striking structural and molecular phenotypes were not associated with an increase in the natriuretic effect of thiazide. In wild-type mice, Hsd11b2 mRNA was detected in some tubule segments expressing Slc12a3, but 11?HSD2 and NCC did not colocalize at the protein level. Thus, the phosphorylation status of NCC may not necessarily equate to its activity in vivo, and the structural remodeling of the DCT in the knockout mouse may not be a direct consequence of aberrant corticosteroid signaling in DCT cells. These observations suggest that the conventional concept of mineralocorticoid signaling in the DCT should be revised to recognize the complexity of NCC regulation by corticosteroids. Twit Text FOAVip Hypertrophy in the Distal Convoluted Tubule of an 11 -Hydroxysteroid Dehydrogenase Type 2 Knockout Model ????J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25349206 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25349206 #FOAvip English Wikipedia <ref>{{Cite pmid|25349206 }}</ref> Hypertrophy in the Distal Convoluted Tubule of an 11?-Hydroxysteroid Dehydrogenase Type 2 Knockout Model #MMPMID25349206 Hunter RW ; Ivy JR ; Flatman PW ; Kenyon CJ ; Craigie E ; Mullins LJ ; Bailey MA ; Mullins JJ J Am Soc Nephrol 2015[Jul]; 26 (7 ): 1537-48 PMID25349206 show ga Na(+) transport in the renal distal convoluted tubule (DCT) by the thiazide-sensitive NaCl cotransporter (NCC) is a major determinant of total body Na(+) and BP. NCC-mediated transport is stimulated by aldosterone, the dominant regulator of chronic Na(+) homeostasis, but the mechanism is controversial. Transport may also be affected by epithelial remodeling, which occurs in the DCT in response to chronic perturbations in electrolyte homeostasis. Hsd11b2(-/-) mice, which lack the enzyme 11?-hydroxysteroid dehydrogenase type 2 (11?HSD2) and thus exhibit the syndrome of apparent mineralocorticoid excess, provided an ideal model in which to investigate the potential for DCT hypertrophy to contribute to Na(+) retention in a hypertensive condition. The DCTs of Hsd11b2(-/-) mice exhibited hypertrophy and hyperplasia and the kidneys expressed higher levels of total and phosphorylated NCC compared with those of wild-type mice. However, the striking structural and molecular phenotypes were not associated with an increase in the natriuretic effect of thiazide. In wild-type mice, Hsd11b2 mRNA was detected in some tubule segments expressing Slc12a3, but 11?HSD2 and NCC did not colocalize at the protein level. Thus, the phosphorylation status of NCC may not necessarily equate to its activity in vivo, and the structural remodeling of the DCT in the knockout mouse may not be a direct consequence of aberrant corticosteroid signaling in DCT cells. These observations suggest that the conventional concept of mineralocorticoid signaling in the DCT should be revised to recognize the complexity of NCC regulation by corticosteroids. |11-beta-Hydroxysteroid Dehydrogenase Type 2/metabolism/*pharmacology [MESH] |Analysis of Variance [MESH] |Animals [MESH] |Cells, Cultured [MESH] |DNA, Complementary/analysis [MESH] |Disease Models, Animal [MESH] |Epithelial Cells/cytology/drug effects [MESH] |Female [MESH] |Hypertrophy/pathology [MESH] |Kidney Tubules, Distal/drug effects/*pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Phosphorylation/*drug effects [MESH] |Polymerase Chain Reaction/methods [MESH] |RNA/analysis [MESH] |Random Allocation [MESH] |Sodium Chloride Symporters/*metabolism [MESH]Hypertrophy in the Distal Convoluted Tubule of an 11?-Hydroxysteroid (epmc).pdf DeepDyve Pubget Overpricing