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10.1093/neuonc/nou279 http://scihub22266oqcxt.onion/10.1093/neuonc/nou279 C4483102!4483102!25395462     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuro+Oncol 2015 ; 17 (3): 448-56 Nephropedia Template TP {{tp|p=25395462|t=2015. Subsequent neoplasms in survivors of childhood central nervous system tumors: risk after modern multimodal therapy |pdf=|usr=}}{{25395462}} gab.com Text Subsequent neoplasms in survivors of childhood central nervous system tumors: risk after modern multimodal therapy JO: Neuro Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25395462 #FOAvip Background: Multimodal therapy has improved survival for some childhood CNS tumors. However, whether risk for subsequent neoplasms (SNs) also increases is unknown. We report the cumulative incidence of, and risk factors for, SNs after a childhood primary CNS tumor and determine whether treatment that combines radiation therapy (RT) with chemotherapy increases risk for SNs. Methods: Analyses included 2779 patients with a primary CNS tumor treated at St Jude Children's Research Hospital between 1985 and 2012. Cumulative incidence and standardized incidence ratios (SIRs) were estimated for SNs confirmed by pathology report. Cumulative incidence among the 237 five-year medulloblastoma survivors treated with multimodal therapy (RT + chemotherapy) was compared with a historical cohort of 139 five-year survivors treated with RT but no chemotherapy in the Childhood Cancer Survivor Study. Results: Eighty-one survivors had 97 SNs. The cumulative incidence of first SN was 3.0% (95% CI: 2.3%?3.9%) at 10 years, and 6.0% (95% CI: 4.6%?7.7%) at 20 years from diagnosis. Risks were highest for subsequent glioma, all grades (SIR = 57.2; 95% CI: 36.2?85.8) and acute myeloid leukemia (SIR = 31.8; 95% CI: 10.2?74.1). Compared with RT alone, RT + chemotherapy did not increase risk for SNs (hazard ratio: 0.64; 95% CI: 0.38?1.06). Among five-year survivors of medulloblastoma treated with multimodal therapy, cumulative incidence of SN was 12.0% (95% CI: 6.4%?19.5%) at 20 years, no different than survivors treated with RT alone (11.3%, P = .44). Conclusion: The cumulative incidence of SNs continues to increase with time from treatment with no obvious plateau, but the risk does not appear to be higher after exposure to multimodal therapy compared with RT alone. Continued follow-up of survivors as they age is essential. Twit Text FOAVip Subsequent neoplasms in survivors of childhood central nervous system tumors: risk after modern multimodal therapy ????Neuro Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25395462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25395462 #FOAvip English Wikipedia <ref>{{Cite pmid|25395462}}</ref> Subsequent neoplasms in survivors of childhood central nervous system tumors: risk after modern multimodal therapy #MMPMID25395462 Tsui K; Gajjar A; Li C; Srivastava D; Broniscer A; Wetmore C; Kun LE; Merchant TE; Ellison DW; Orr BA; Boop FA; Klimo P; Ross J; Robison LL; Armstrong GT Neuro Oncol 2015[Mar]; 17 (3): 448-56 PMID25395462show ga Background: Multimodal therapy has improved survival for some childhood CNS tumors. However, whether risk for subsequent neoplasms (SNs) also increases is unknown. We report the cumulative incidence of, and risk factors for, SNs after a childhood primary CNS tumor and determine whether treatment that combines radiation therapy (RT) with chemotherapy increases risk for SNs. Methods: Analyses included 2779 patients with a primary CNS tumor treated at St Jude Children's Research Hospital between 1985 and 2012. Cumulative incidence and standardized incidence ratios (SIRs) were estimated for SNs confirmed by pathology report. Cumulative incidence among the 237 five-year medulloblastoma survivors treated with multimodal therapy (RT + chemotherapy) was compared with a historical cohort of 139 five-year survivors treated with RT but no chemotherapy in the Childhood Cancer Survivor Study. Results: Eighty-one survivors had 97 SNs. The cumulative incidence of first SN was 3.0% (95% CI: 2.3%?3.9%) at 10 years, and 6.0% (95% CI: 4.6%?7.7%) at 20 years from diagnosis. Risks were highest for subsequent glioma, all grades (SIR = 57.2; 95% CI: 36.2?85.8) and acute myeloid leukemia (SIR = 31.8; 95% CI: 10.2?74.1). Compared with RT alone, RT + chemotherapy did not increase risk for SNs (hazard ratio: 0.64; 95% CI: 0.38?1.06). Among five-year survivors of medulloblastoma treated with multimodal therapy, cumulative incidence of SN was 12.0% (95% CI: 6.4%?19.5%) at 20 years, no different than survivors treated with RT alone (11.3%, P = .44). Conclusion: The cumulative incidence of SNs continues to increase with time from treatment with no obvious plateau, but the risk does not appear to be higher after exposure to multimodal therapy compared with RT alone. Continued follow-up of survivors as they age is essential. äSubsequent neoplasms in survivors of childhood central nervous system (epmc).pdf DeepDyve Pubget Overpricing