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10.1093/neuonc/nou312 http://scihub22266oqcxt.onion/10.1093/neuonc/nou312 C4482857!4482857!25416827     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuro+Oncol 2015 ; 17 (5): 718-24 Nephropedia Template TP {{tp|p=25416827|t=2015. The long-term risk of malignant astrocytic tumors after structural brain injury?a nationwide cohort study |pdf=|usr=}}{{25416827}} gab.com Text The long-term risk of malignant astrocytic tumors after structural brain injury a nationwide cohort study JO: Neuro Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25416827 #FOAvip Background: Neoplastic transformation of damaged astrocytes has been proposed as a possible pathological mechanism behind malignant astrocytic tumors. This study investigated the association between structural brain injuries causing reactive astrogliosis and long-term risk for malignant astrocytic tumors. Methods: The cohort consisted of all individuals living in Denmark between 1978 and 2011. The personal identification number assigned to all individuals allowed retrieval of diagnoses of traumatic brain injury, cerebral ischemic infarction, and intracerebral hemorrhage from the National Patient Discharge Register. Diagnoses of anaplastic astrocytoma and glioblastoma multiforme (World Health Organization grades III and IV) were retrieved from the Danish Cancer Registry. Rate ratios (RR's) were estimated using log-linear Poisson regression. Results: In a cohort of 8.2 million individuals, 404 812 experienced a structural brain injury and 6152 developed a malignant astrocytic tumor. No significant association was observed 1?4 years after a structural brain injury (RR = 1.14; 95% CI: 0.87?1.46), whereas the long-term (5+ y) risk for malignant astrocytic tumors was significantly reduced (RR = 0.68; 95% CI: 0.49?0.90) compared with no injury. The specific long-term risks by type of injury were: traumatic brain injury RR = 0.32 (95% CI: 0.10?0.75); cerebral ischemic infarction RR = 0.69 (95% CI: 0.47?0.96); and intracerebral hemorrhage RR = 1.39 (95% CI: 0.64?2.60). Conclusion: We found no evidence for an association between structural brain injury and malignant astrocytic tumors within the first 5 years of follow-up. However, our study indicated a protective effect of astrogliosis-causing injuries 5 or more years after structural brain injury. Twit Text FOAVip The long-term risk of malignant astrocytic tumors after structural brain injury a nationwide cohort study ????Neuro Oncol http://www.kidney.de/pget.php?&tw=1&pmid=25416827 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25416827 #FOAvip English Wikipedia <ref>{{Cite pmid|25416827}}</ref> The long-term risk of malignant astrocytic tumors after structural brain injury?a nationwide cohort study #MMPMID25416827 Munch TN; Gørtz S; Wohlfahrt J; Melbye M Neuro Oncol 2015[May]; 17 (5): 718-24 PMID25416827show ga Background: Neoplastic transformation of damaged astrocytes has been proposed as a possible pathological mechanism behind malignant astrocytic tumors. This study investigated the association between structural brain injuries causing reactive astrogliosis and long-term risk for malignant astrocytic tumors. Methods: The cohort consisted of all individuals living in Denmark between 1978 and 2011. The personal identification number assigned to all individuals allowed retrieval of diagnoses of traumatic brain injury, cerebral ischemic infarction, and intracerebral hemorrhage from the National Patient Discharge Register. Diagnoses of anaplastic astrocytoma and glioblastoma multiforme (World Health Organization grades III and IV) were retrieved from the Danish Cancer Registry. Rate ratios (RR's) were estimated using log-linear Poisson regression. Results: In a cohort of 8.2 million individuals, 404 812 experienced a structural brain injury and 6152 developed a malignant astrocytic tumor. No significant association was observed 1?4 years after a structural brain injury (RR = 1.14; 95% CI: 0.87?1.46), whereas the long-term (5+ y) risk for malignant astrocytic tumors was significantly reduced (RR = 0.68; 95% CI: 0.49?0.90) compared with no injury. The specific long-term risks by type of injury were: traumatic brain injury RR = 0.32 (95% CI: 0.10?0.75); cerebral ischemic infarction RR = 0.69 (95% CI: 0.47?0.96); and intracerebral hemorrhage RR = 1.39 (95% CI: 0.64?2.60). Conclusion: We found no evidence for an association between structural brain injury and malignant astrocytic tumors within the first 5 years of follow-up. However, our study indicated a protective effect of astrogliosis-causing injuries 5 or more years after structural brain injury. äThe long-term risk of malignant astrocytic tumors after structural bra(epmc).pdf DeepDyve Pubget Overpricing