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2015 ; 9
(ä): 3179-82
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The impact of lipocalin-type-prostaglandin-D-synthase as a predictor of kidney
disease in patients with type 2 diabetes
#MMPMID26124640
Bacci MR
; Cavallari MR
; de Rozier-Alves RM
; Alves Bda C
; Fonseca FL
Drug Des Devel Ther
2015[]; 9
(ä): 3179-82
PMID26124640
show ga
Hypertension and diabetes are clinical conditions which contribute to the
development of chronic kidney disease as well as risk factors for cardiovascular
events. In recent years, lipocalin-type-prostaglandin-D-synthase (beta trace
protein; BTP) has increasingly been studied as an alternative to creatinine for
the evaluation of renal function as well as for being a possible biomarker for
cardiovascular disease. It is expected that the levels of BTP in patients with
cardiovascular disease are elevated, as is the case with patients with renal
dysfunction. The objective of this study is to realize a systematic review of the
pertinent literature in respect to BTP as a biomarker of renal dysfunction in
diabetic patients. Using the database MEDLINE, a search up to year 2014 was
conducted using the follow descriptors: "lipocalin type prostaglandin d synthase"
AND "diabetes"; "lipocalin type prostaglandin d synthase" and "diabetic
nephropathy"; "beta trace protein" AND "diabetes"; "beta trace protein" AND
"diabetic nephropathy". The criteria used for inclusion were the presence of the
referring to terms in title or abstract and study conducted in humans. About 17
articles were selected, of which six articles were duplicates, and of which six
articles did not investigate any possible relationship between the protein (BTP)
and either diabetes or nephropathy. The final result yielded five articles to be
analyzed. This review found BTP is not influenced by race, by body mass index nor
by patient's sex. BTP can be considered as a reliable early biomarker of renal
dysfunction in diabetics. BTP is associated with metabolic syndrome and is also
associated with greater cardiovascular risk. Prospective data establishing a
correlation between BTP and mortality would have been of great interest, but such
articles were not found in this review.
|Animals
[MESH]
|Biomarkers/metabolism
[MESH]
|Diabetes Mellitus, Type 2/complications/diagnosis/*enzymology/physiopathology
[MESH]