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10.1093/nar/gkv361 http://scihub22266oqcxt.onion/10.1093/nar/gkv361 C4482088!4482088!25897130     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2015 ; 43 (9): 4614-26 Nephropedia Template TP {{tp|p=25897130|t=2015. BLM unfolds G-quadruplexes in different structural environments through different mechanisms |pdf=|usr=}}{{25897130}} gab.com Text BLM unfolds G-quadruplexes in different structural environments through different mechanisms JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=25897130 #FOAvip Mutations in the RecQ DNA helicase gene BLM give rise to Bloom's syndrome, which is a rare autosomal recessive disorder characterized by genetic instability and cancer predisposition. BLM helicase is highly active in binding and unwinding G-quadruplexes (G4s), which are physiological targets for BLM, as revealed by genome-wide characterizations of gene expression of cells from BS patients. With smFRET assays, we studied the molecular mechanism of BLM-catalyzed G4 unfolding and showed that ATP is required for G4 unfolding. Surprisingly, depending on the molecular environments of G4, BLM unfolds G4 through different mechanisms: unfolding G4 harboring a 3?-ssDNA tail in three discrete steps with unidirectional translocation, and unfolding G4 connected to dsDNA by ssDNA in a repetitive manner in which BLM remains anchored at the ss/dsDNA junction, and G4 was unfolded by reeling in ssDNA. This indicates that one BLM molecule may unfold G4s in different molecular environments through different mechanisms. Twit Text FOAVip BLM unfolds G-quadruplexes in different structural environments through different mechanisms ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=25897130 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25897130 #FOAvip English Wikipedia <ref>{{Cite pmid|25897130}}</ref> BLM unfolds G-quadruplexes in different structural environments through different mechanisms #MMPMID25897130 Wu WQ; Hou XM; Li M; Dou SX; Xi XG Nucleic Acids Res 2015[May]; 43 (9): 4614-26 PMID25897130show ga Mutations in the RecQ DNA helicase gene BLM give rise to Bloom's syndrome, which is a rare autosomal recessive disorder characterized by genetic instability and cancer predisposition. BLM helicase is highly active in binding and unwinding G-quadruplexes (G4s), which are physiological targets for BLM, as revealed by genome-wide characterizations of gene expression of cells from BS patients. With smFRET assays, we studied the molecular mechanism of BLM-catalyzed G4 unfolding and showed that ATP is required for G4 unfolding. Surprisingly, depending on the molecular environments of G4, BLM unfolds G4 through different mechanisms: unfolding G4 harboring a 3?-ssDNA tail in three discrete steps with unidirectional translocation, and unfolding G4 connected to dsDNA by ssDNA in a repetitive manner in which BLM remains anchored at the ss/dsDNA junction, and G4 was unfolded by reeling in ssDNA. This indicates that one BLM molecule may unfold G4s in different molecular environments through different mechanisms. äBLM unfolds G-quadruplexes in different structural environments throug(epmc).pdf DeepDyve Pubget Overpricing