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10.1038/ncomms8562 http://scihub22266oqcxt.onion/10.1038/ncomms8562 C4481879!4481879!26108174     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26108174|t=2015. IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection |pdf=|usr=}}{{26108174}} gab.com Text IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26108174 #FOAvip Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated with chronic HIV-1 control, it is not known whether interleukin-21 (IL-21) contributes to early HIV-1 immunity. Here we take advantage of tractable primary human lymphoid organ aggregate cultures to show that IL-21 directly suppresses HIV-1 replication, and identify microRNA-29 (miR-29) as an antiviral factor induced by IL-21 in CD4 T cells. IL-21 promotes transcription of all miR-29 species through STAT3, whose binding to putative regulatory regions within the MIR29 gene is enriched by IL-21 signalling. Notably, exogenous IL-21 limits early HIV-1 infection in humanized mice, and lower viremia in vivo is associated with higher miR-29 expression. Together, these findings reveal a novel antiviral IL-21-miR-29 axis that promotes CD4 T-cell-intrinsic resistance to HIV-1 infection, and suggest a role for IL-21 in initial HIV-1 control in vivo. Twit Text FOAVip IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26108174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26108174 #FOAvip English Wikipedia <ref>{{Cite pmid|26108174}}</ref> IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection #MMPMID26108174 Adoro S; Cubillos-Ruiz JR; Chen X; Deruaz M; Vrbanac VD; Song M; Park S; Murooka TT; Dudek TE; Luster AD; Tager AM; Streeck H; Bowman B; Walker BD; Kwon DS; Lazarevic V; Glimcher LH Nat Commun 2015[]; 6 (ä): ä PMID26108174show ga Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated with chronic HIV-1 control, it is not known whether interleukin-21 (IL-21) contributes to early HIV-1 immunity. Here we take advantage of tractable primary human lymphoid organ aggregate cultures to show that IL-21 directly suppresses HIV-1 replication, and identify microRNA-29 (miR-29) as an antiviral factor induced by IL-21 in CD4 T cells. IL-21 promotes transcription of all miR-29 species through STAT3, whose binding to putative regulatory regions within the MIR29 gene is enriched by IL-21 signalling. Notably, exogenous IL-21 limits early HIV-1 infection in humanized mice, and lower viremia in vivo is associated with higher miR-29 expression. Together, these findings reveal a novel antiviral IL-21-miR-29 axis that promotes CD4 T-cell-intrinsic resistance to HIV-1 infection, and suggest a role for IL-21 in initial HIV-1 control in vivo. äIL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infe(epmc).pdf DeepDyve Pubget Overpricing