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10.4049/jimmunol.1403158 http://scihub22266oqcxt.onion/10.4049/jimmunol.1403158 C4481326!4481326!25870244     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 194 (10): 4784-95 Nephropedia Template TP {{tp|p=25870244|t=2015. Young, proliferative thymic epithelial cells engraft and function in aging thymuses |pdf=|usr=}}{{25870244}} gab.com Text Young, proliferative thymic epithelial cells engraft and function in aging thymuses JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25870244 #FOAvip The thymus reaches its maximum size early in life and then begins to shrink, producing fewer T cells with increasing age. This thymic decline is thought to contribute to age-related T cell lymphopenias and hinder T cell recovery following bone marrow transplantation. While several cellular and molecular processes have been implicated in age-related thymic involution, their relative contributions are not known. Using heterochronic parabiosis, we observe that young circulating factors are not sufficient to drive regeneration of the aged thymus. In contrast, we find that resupplying young, engraftable thymic epithelial cells to a middle-aged or defective thymus leads to thymic growth and increased T cell production. Intrathymic transplantation and in vitro colony forming assays reveal that the engraftment and proliferative capacities of thymic epithelial cells diminish early in life, whereas the receptivity of the thymus to thymic epithelial cell engraftment remains relatively constant with age. These results support a model in which thymic growth and subsequent involution are driven by cell intrinsic changes in the proliferative capacity of thymic epithelial cells, and further show that young thymic epithelial cells can engraft and directly drive the growth of involuted thymuses. Twit Text FOAVip Young, proliferative thymic epithelial cells engraft and function in aging thymuses ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25870244 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25870244 #FOAvip English Wikipedia <ref>{{Cite pmid|25870244}}</ref> Young, proliferative thymic epithelial cells engraft and function in aging thymuses #MMPMID25870244 Kim MJ; Miller CM; Shadrach JL; Wagers AJ; Serwold T J Immunol 2015[May]; 194 (10): 4784-95 PMID25870244show ga The thymus reaches its maximum size early in life and then begins to shrink, producing fewer T cells with increasing age. This thymic decline is thought to contribute to age-related T cell lymphopenias and hinder T cell recovery following bone marrow transplantation. While several cellular and molecular processes have been implicated in age-related thymic involution, their relative contributions are not known. Using heterochronic parabiosis, we observe that young circulating factors are not sufficient to drive regeneration of the aged thymus. In contrast, we find that resupplying young, engraftable thymic epithelial cells to a middle-aged or defective thymus leads to thymic growth and increased T cell production. Intrathymic transplantation and in vitro colony forming assays reveal that the engraftment and proliferative capacities of thymic epithelial cells diminish early in life, whereas the receptivity of the thymus to thymic epithelial cell engraftment remains relatively constant with age. These results support a model in which thymic growth and subsequent involution are driven by cell intrinsic changes in the proliferative capacity of thymic epithelial cells, and further show that young thymic epithelial cells can engraft and directly drive the growth of involuted thymuses. äYoung, proliferative thymic epithelial cells engraft and function in a(epmc).pdf DeepDyve Pubget Overpricing