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10.1074/jbc.M115.661405

http://scihub22266oqcxt.onion/10.1074/jbc.M115.661405
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C4481231!4481231!25953898
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suck abstract from ncbi


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pmid25953898      J+Biol+Chem 2015 ; 290 (26): 16330-42
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  • Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties* #MMPMID25953898
  • Schuepbach-Mallepell S; Das D; Willen L; Vigolo M; Tardivel A; Lebon L; Kowalczyk-Quintas C; Nys J; Smulski C; Zheng TS; Maskos K; Lammens A; Jiang X; Hess H; Tan SL; Schneider P
  • J Biol Chem 2015[Jun]; 290 (26): 16330-42 PMID25953898show ga
  • Background: The B cell survival factors B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) can heteromerize.Results: BAFF-APRIL2 and APRIL-BAFF2 heteromers have distinct receptor-binding specificities and activities.Conclusion: BAFF-APRIL2 resembles APRIL, and APRIL-BAFF2 resembles BAFF but poorly activates the BAFF receptor.Significance: Heteromers should be taken into account when evaluating the physiology or pharmacological inhibition of BAFF and APRIL.
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