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10.1074/jbc.M115.645812

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C4481200!4481200!25861985
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suck abstract from ncbi


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pmid25861985      J+Biol+Chem 2015 ; 290 (26): 15949-60
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  • Human Urinary Composition Controls Antibacterial Activity of Siderocalin*? #MMPMID25861985
  • Shields-Cutler RR; Crowley JR; Hung CS; Stapleton AE; Aldrich CC; Marschall J; Henderson JP
  • J Biol Chem 2015[Jun]; 290 (26): 15949-60 PMID25861985show ga
  • Background: During urinary tract infections, humans secrete the protein siderocalin to block bacterial iron uptake.Results: Human urinary pH and metabolite composition strongly affect siderocalin's antibacterial activity.Conclusion: Siderocalin uses a subset of urinary metabolites as cofactors to withhold iron from E. coli in competition with the bacterial siderophore enterobactin.Significance: Therapeutic control of urinary composition may facilitate an important innate antibacterial defense.
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